Location
LSU Health Sciences Center - New Orleans
Event Website
https://digitalscholar.lsuhsc.edu/surgery_s/
Document Type
Event
Start Date
4-5-2023 10:20 AM
End Date
4-5-2023 10:30 AM
Description
Introduction:
The overall incidence of colorectal cancer (CRC) has been decreasing in the United States, however disparities remain with certain age and race groups. Data has indicated that African American patients under 50 years of age have an increasing incidence of CRC. Additionally, their overall rate of CRC is declining more slowly when compared to White and Asian races. It is important to explore these trends in order to determine if reducing screening age guidelines for African Americans is beneficial.
Methods:
The Cancer Query System of the Surveillance, Epidemiology, and End Results Program (SEER) database was used to obtain incidence statistics. We performed a retrospective analysis of 20 to 79 year old patients with CRC from 1975-2017 by race: White, Black, and other. Incidence graphs were compiled for both data sets with five-year intervals from 20 years old to 79 years old. Additionally, the data has been configured into graphs showing the mean age and stage at diagnosis for each race category. A chi-square test was used to analyze categorical variables, and an independent t-test for continuous nonparametric data.
Results:
The overall incidence of CRC for all races decreased by 36.4%. African Americans showed the smallest percent decrease at 19.2%, as compared to Whites at 39.3% decrease, and Other (American Indian, AK Native, Asian/Pacific Islander) at a 24% decrease. Amongst the 45-49 year age range, incidence of CRC in Whites was 17.9 per 100,000 people, and 69.9 per 100,000 in Blacks. From 1992-2015, the average age at diagnosis for CRC in Blacks was 61 ± 11 years, while it was found to be 63 ± 11 years in Whites (p<0.001). Lastly, the data indicated that African Americans were more likely to present with metastasis compared to Whites at time of diagnosis (26.6% vs 24.3%, p<0.001).
Conclusion:
Our data confirms increased incidence of CRC in African Americans younger than 50 years of age. In addition, African Americans are more likely to present with greater stage tumors (Stage IV) at diagnosis. It is imperative to create methods that will eradicate the racial disparities through educating these patient populations about their risk factors and the importance of screening for cancer. Additionally it will be useful to consider decreasing the screening age for CRC in African American patient populations to 45 years of age rather than the current guideline of 50 years old.
Recommended Citation
Hargis, McKenzie; Saeed, Sabine; Thompson, Elijah; Villa, Cassandra; and Nfonsam, Valentine, "Elucidating the Racial Disparity in the Age and Stage at Diagnosis of Colorectal Cancer" (2023). Surgery Research Symposium. 13.
https://digitalscholar.lsuhsc.edu/surgery_s/2023/postera/13
Included in
Elucidating the Racial Disparity in the Age and Stage at Diagnosis of Colorectal Cancer
LSU Health Sciences Center - New Orleans
Introduction:
The overall incidence of colorectal cancer (CRC) has been decreasing in the United States, however disparities remain with certain age and race groups. Data has indicated that African American patients under 50 years of age have an increasing incidence of CRC. Additionally, their overall rate of CRC is declining more slowly when compared to White and Asian races. It is important to explore these trends in order to determine if reducing screening age guidelines for African Americans is beneficial.
Methods:
The Cancer Query System of the Surveillance, Epidemiology, and End Results Program (SEER) database was used to obtain incidence statistics. We performed a retrospective analysis of 20 to 79 year old patients with CRC from 1975-2017 by race: White, Black, and other. Incidence graphs were compiled for both data sets with five-year intervals from 20 years old to 79 years old. Additionally, the data has been configured into graphs showing the mean age and stage at diagnosis for each race category. A chi-square test was used to analyze categorical variables, and an independent t-test for continuous nonparametric data.
Results:
The overall incidence of CRC for all races decreased by 36.4%. African Americans showed the smallest percent decrease at 19.2%, as compared to Whites at 39.3% decrease, and Other (American Indian, AK Native, Asian/Pacific Islander) at a 24% decrease. Amongst the 45-49 year age range, incidence of CRC in Whites was 17.9 per 100,000 people, and 69.9 per 100,000 in Blacks. From 1992-2015, the average age at diagnosis for CRC in Blacks was 61 ± 11 years, while it was found to be 63 ± 11 years in Whites (p<0.001). Lastly, the data indicated that African Americans were more likely to present with metastasis compared to Whites at time of diagnosis (26.6% vs 24.3%, p<0.001).
Conclusion:
Our data confirms increased incidence of CRC in African Americans younger than 50 years of age. In addition, African Americans are more likely to present with greater stage tumors (Stage IV) at diagnosis. It is imperative to create methods that will eradicate the racial disparities through educating these patient populations about their risk factors and the importance of screening for cancer. Additionally it will be useful to consider decreasing the screening age for CRC in African American patient populations to 45 years of age rather than the current guideline of 50 years old.
https://digitalscholar.lsuhsc.edu/surgery_s/2023/postera/13