Notch pathway: a journey from notching phenotypes to cancer immunotherapy
Document Type
Article
Publication Date
10-9-2020
Publication Title
Advances in Experimental Medicine and Biology
Abstract
Notch is a key evolutionary conserved pathway, which has fascinated and engaged the work of investigators in an uncountable number of biological fields, from development of metazoans to immunotherapy for cancer. The study of Notch has greatly contributed to the understanding of cancer biology and a substantial effort has been spent in designing Notch-targeting therapies. Due to its broad involvement in cancer, targeting Notch would allow to virtually modulate any aspect of the disease. However, this means that Notch-based therapies must be highly specific to avoid off-target effects. This review will present the newest mechanistic and therapeutic advances in the Notch field and discuss the promises and challenges of this constantly evolving field.
First Page
201
Last Page
222
PubMed ID
33034034
Volume
1287
Publisher
Springer
Recommended Citation
Monticone, Giulia and Miele, Lucio, "Notch pathway: a journey from notching phenotypes to cancer immunotherapy" (2020). School of Medicine Faculty Publications. 88.
https://digitalscholar.lsuhsc.edu/som_facpubs/88
10.1007/978-3-030-55031-8_13