Long- and short-term effects of carbaryl exposure in chick embryos

Document Type

Article

Publication Date

12-1-1981

Publication Title

Envrionmental Research

Abstract

The effects of carbaryl on chick embryos following 5 and 12 days of exposure were examined. Carbaryl was dissolved in two vehicles (acetone and sesame oil) and the roles of these two vehicles in avian embryogenesis were assessed. The dosages of carbaryl used were 10, 5, 2.5, and 1.0 mg. All injections were administered prior to incubation. Groups of embryos exposed for 5 days to carbaryl in sesame oil and acetone showed a significant increase in mortality over their respective vehicle controls. There were no indications of external abnormalities in any of the 5-day surviving embryos regardless of how they were exposed. Those embryos exposed to carbaryl for 12 days demonstrated a significant increase in mortality over similarly treated 5-day groups; however, a greater embryotoxicity still occurred in those embryos exposed to carbaryl in sesame oil. Subcutaneous edema was a common defect seen in embryos receiving the higher dosages of carbaryl in acetone. Lower-limb abnormalities were less commonly observed. Results of this study demonstrate an increased embryotoxicity of carbaryl in sesame oil as opposed to acetone at all dosages employed. It is also apparent that carbaryl can become incorporated into the embryo from the yolk sac within 5 days, but a longer period of exposure is necessary for external abnormalities to occur.

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