New Opioid Receptor Modulators and Agonists| Ch 4

Document Type

Book Chapter

Publication Date

9-26-2025

Editor

Scott Edwards et al

Abstract

As medical advancements focus more on patient-centered care, there is an increased demand for individualized treatment options. In the context of opioids, precision medicine offers a promising avenue to address the complex challenges of pain management and opioid use disorder treatment. This transformative approach to opioid prescribing offers a chance to preemptively assess a patient's risk for dependence and overdose. This chapter addresses the historical trends of personalized care as it relates to combating the opioid epidemic. Obstacles related to ethical considerations and the feasibility of precision medicine implementation are explored. Understanding the role of Cytochrome P450 (CYP450) enzymes in drug metabolism is crucial for optimizing therapy. This chapter highlights how genetic variability in CYP450 enzymes can significantly impact opioid metabolism and efficacy, informing personalized dosing strategies. Integrating precision medicine into clinical holds substantial potential to end “one-size-fits-all” opioid prescribing while mitigating risk factors and impacting the public health crisis of opioid misuse.

First Page

33

Last Page

40

Chapter Title

Chapter 4 - Pharmacogenomics/precision medicine: Opioid-related interactions and metabolism considerations

Publisher

Academic Press

ISBN

[9780443265051, 9780443265044]

Rights

Copyright © 2026 Elsevier Inc.

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