Proteome-wide association study of prostate cancer risk across populations

Authors

Hua Zhong, LSU Health Sciences Center - New OrleansFollow
Jingjing Zhu, LSU Health Sciences Center - New OrleansFollow
Shuai Liu, LSU Health Sciences Center - New OrleansFollow
Chong Wu, The University of Texas MD Anderson Cancer Center, Houston, TX
Liang Wang, Moffitt Cancer Center, Tampa, FL
Seamus P. Whelton, Johns Hopkins School of Medicine, Baltimore, MD
Catherine H. Marshall, Johns Hopkins University, Baltimore, MD
Michael J. Blaha, Johns Hopkins Hospital, Baltimore, MD
Peter Durda, University of Vermont, Burlington, VT
Xiuqing Guo, Harbor-UCLA Medical Center, Torrance, CA
Craig W. Johnson, University of Washington, Seattle, WA
Henry J. Lin, Harbor-UCLA Medical Center, Torrance, CA
Kent D. Taylor, Harbor-UCLA Medical Center, Torrance, CA
Russell P. Tracy, University of Vermont, Burlington, VT
Ronit I. Yarden, Lung and Blood Institute, Bethesda, MD
Ani W. Manichaikul, University of Virginia, Charlottesville, VA
Stephen S. Rich, University of Virginia, Charlottesville, VA
Jerome I. Rotter, Harbor-UCLA Medical Center, Torrance, CA
Rajat Deo, University of Pennsylvania, Philadelphia, PA
Ruth F. Dubin, University of Texas Southwestern Medical Center, Dallas, TX
Peter Ganz, University of California San Francisco, San Francisco, CAFollow
Lang Wu, LSU Health Sciences Center - New OrleansFollow

Document Type

Article

Publication Date

12-6-2025

Publication Title

Nature Communications

Abstract

There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be associated with PCa risk across populations. We develop genetic prediction models for expression of 1578, 1993, 1218, and 1390 proteins for African (n = 450), European (n = 758), Asian (n = 289), and Hispanic/Latino (n = 474) males, respectively, and evaluate associations of genetically regulated protein expression with PCa risk in 19,391 PCa cases and 61,608 controls of African population, 122,188 cases and 604,640 controls of European population, 10,809 cases and 95,790 controls of Asian population, and 3931 cases and 26,405 controls of Hispanic/Latino population. We identify three, four, 15, and 73 PCa-associated proteins in African, Hispanic/Latino, Asian, and European populations, respectively, and 83 in trans-population meta-analysis. There are both pan-population and population-specific associations. Our findings provide valuable insights into etiology of PCa.

PubMed ID

41353205

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Zhong, Hua; Zhu, Jingjing; Liu, Shuai; Wu, Chong; Wang, Liang; Whelton, Seamus P.; Marshall, Catherine H.; Blaha, Michael J.; Durda, Peter; Guo, Xiuqing; Johnson, Craig W.; Lin, Henry J.; Taylor, Kent D.; Tracy, Russell P.; Yarden, Ronit I.; Manichaikul, Ani W.; Rich, Stephen S.; Rotter, Jerome I.; Deo, Rajat; Dubin, Ruth F.; Ganz, Peter; and Wu, Lang, "Proteome-wide association study of prostate cancer risk across populations" (2025). School of Graduate Studies Faculty Publications. 476.
https://digitalscholar.lsuhsc.edu/sogs_facpubs/476
10.1038/s41467-025-66250-5