“The contributions of race, age, and anticoagulant Protein S in predicting COVID-19 prognosis”
Publication Date
Summer July 2020
Location
Virtual
Document Type
Presentation
Start Date
1-7-2020 10:00 AM
Description
The COVID 19 pandemic has caused monumental mortality, and there is, as yet, no adequate therap y Unlike the SARS CoV pandemic in 2003, COVID 19 is not simply a disease of the upper respiratory tract. COVID 19 pat ients experience hypercoagulability and increased risk of venous thromboembolism. Severe cases of COVID 19 i.e., patients who require ventilators involve hyper coagula bility and disseminated intravascular coagulation ( Moreover, several reports indicate that hypercoagulability, as measured by the D Dimer level, is present mostly in critically ill and deceased patients. In addition to blood clots of all sizes throug hout the body, doctors who treat coronavirus patients report a range of other odd and frightening syndromes, such as kidney failure, cardiac inflammation, and immune complications. D eficiency of the plasma anticoagulant Protein S is associated with DIC and thrombosis. Ordinarily, Protein S deficiency is due either to homozygous or he terozygous genetic alteration, and Protein S deficiency can result from various pathological states and diseases. In all these cases, Protein S deficiency is associated with a high risk of venous thrombosis. Protein S limits thrombin generation by directly inhibiting Factor IXa Thus, the high thrombotic risk associated with PS deficiency is due to failure t o regulate thrombin formation Clinicians measure the D dimer level s of COVID 19 patients because D dimer level is indicative of hypercoagulability and DIC. A positive D dimer result indicates the presence of an abnormally high level of fibrin degradation products thus high D dimer suggest s substantial blood clot ( formation and consequent degradation Interestingly, race and age affect the severity of COVID 19 and the degree of mortality. The elderly are more susceptible to contracting COVID 19 and they have a higher risk of mortality compared with younger individuals In addition, p eople of African and Hispanic origin are also at higher risk of infec tion The purpose of this research was to identify factors that can predict the risk of severe COVID 19 and its prognosis. We found that age, race and the plas ma level of anticoagulant Protein S comprise a list of risk factors that lead to severity and mortality of COVID 19. However, experimental data are required to directly correlate Protein S level with severity of COVID 19 disease.
Recommended Citation
Collins, Taylor K., "“The contributions of race, age, and anticoagulant Protein S in predicting COVID-19 prognosis”" (2020). Summer Research Internship Program. 4.
https://digitalscholar.lsuhsc.edu/srip/2020/undergrad/4
“The contributions of race, age, and anticoagulant Protein S in predicting COVID-19 prognosis”
Virtual
The COVID 19 pandemic has caused monumental mortality, and there is, as yet, no adequate therap y Unlike the SARS CoV pandemic in 2003, COVID 19 is not simply a disease of the upper respiratory tract. COVID 19 pat ients experience hypercoagulability and increased risk of venous thromboembolism. Severe cases of COVID 19 i.e., patients who require ventilators involve hyper coagula bility and disseminated intravascular coagulation ( Moreover, several reports indicate that hypercoagulability, as measured by the D Dimer level, is present mostly in critically ill and deceased patients. In addition to blood clots of all sizes throug hout the body, doctors who treat coronavirus patients report a range of other odd and frightening syndromes, such as kidney failure, cardiac inflammation, and immune complications. D eficiency of the plasma anticoagulant Protein S is associated with DIC and thrombosis. Ordinarily, Protein S deficiency is due either to homozygous or he terozygous genetic alteration, and Protein S deficiency can result from various pathological states and diseases. In all these cases, Protein S deficiency is associated with a high risk of venous thrombosis. Protein S limits thrombin generation by directly inhibiting Factor IXa Thus, the high thrombotic risk associated with PS deficiency is due to failure t o regulate thrombin formation Clinicians measure the D dimer level s of COVID 19 patients because D dimer level is indicative of hypercoagulability and DIC. A positive D dimer result indicates the presence of an abnormally high level of fibrin degradation products thus high D dimer suggest s substantial blood clot ( formation and consequent degradation Interestingly, race and age affect the severity of COVID 19 and the degree of mortality. The elderly are more susceptible to contracting COVID 19 and they have a higher risk of mortality compared with younger individuals In addition, p eople of African and Hispanic origin are also at higher risk of infec tion The purpose of this research was to identify factors that can predict the risk of severe COVID 19 and its prognosis. We found that age, race and the plas ma level of anticoagulant Protein S comprise a list of risk factors that lead to severity and mortality of COVID 19. However, experimental data are required to directly correlate Protein S level with severity of COVID 19 disease.
Comments
Mentor: Dr. Rinku Majumder, PhD.