Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Authors

Jie Shen, Children's Hospital of Soochow University, Suzhou, China
Wander Valentim, Yale School of Medicine, New Haven, CT
Eleni Friligkou, Yale School of Medicine, New Haven, CT
Cassie Overstreet, Yale School of Medicine, New Haven, CT
Karmel W. Choi, Harvard T.H. Chan School of Public Health, Boston, MA
Dora Koller, Yale School of Medicine, New Haven, CT
Christopher J. O’Donnell, Veterans Affairs Boston Healthcare System, West Roxbury, MA
Murray B. Stein, University of California, San Diego
Joel Gelernter, Yale School of Medicine, New Haven, CT
Haitao Lv, Children’s Hospital of Soochow University, Suzhou, China
Ling Sun, Children’s Hospital of Soochow University, Suzhou, China
Guido J. Falcone, Yale University, New Haven, CT
Renato Polimanti, Yale University School of Medicine, New Haven, CT
Gita A. Pathak, Yale University School of Medicine, New Haven, CT
Edward TrapidoFollow
Ariane Rung, LSU Health Sciences Center - New OrleansFollow
et al., Posttraumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium

Document Type

Article

Publication Date

7-1-2025

Publication Title

Nature Communications

Abstract

Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life’s Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions. Potentially shared causal variants between post-traumatic stress disorder and 17 cardiovascular conditions were observed in 11 regions. Subsequent observational analysis in AllofUS cohort showed post-traumatic stress disorder is associated with 13 diagnoses even after accounting for socioeconomic factors and depression. Genetically regulated proteome expression in brain and blood tissues identified 33 blood and 122 brain genes shared between the two conditions, revealing neuronal, immune, metabolic, and calcium-related mechanisms, with several genes as targets for existing drugs. These findings exhibit shared risk loci and genes are involved in tissue-specific mechanisms.

PubMed ID

40595462

Volume

16

Issue

1

Comments

See article for full author list.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Recommended Citation

Shen, Jie; Valentim, Wander; Friligkou, Eleni; Overstreet, Cassie; Choi, Karmel W.; Koller, Dora; O’Donnell, Christopher J.; Stein, Murray B.; Gelernter, Joel; Lv, Haitao; Sun, Ling; Falcone, Guido J.; Polimanti, Renato; Pathak, Gita A.; Trapido, Edward; Rung, Ariane; and al., et, "Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses" (2025). School of Public Health Faculty Publications. 514.
https://digitalscholar.lsuhsc.edu/soph_facpubs/514
10.1038/s41467-025-60487-w