Document Type
Article
Publication Date
4-22-2024
Publication Title
BMJ Open
Abstract
Introduction Cabotegravir long-acting injectable HIV pre-exposure prophylaxis (LA-PrEP) was shown to be safe and effective in multiple clinical trials. Increasing uptake and persistence among populations with elevated risk for HIV acquisition, especially among men who have sex with men (MSM), is critical to HIV prevention. Objective This analysis aims to understand potential users' preferences for LA-PrEP, with audience segmentation. Design Willingness to use and preferences for LA-PrEP were measured in HIV-negative, sexually active MSM in the 2020 American Men's Internet Survey. Respondents answered a discrete choice experiment with paired profiles of hypothetical LA-PrEP characteristics with an opt-out option (no LA-PrEP). Conditional and mixed logit models were run; the final model was a dummy-coded mixed logit that interacted with the opt-out. Setting US national online sample. Results Among 2506 MSM respondents, most (75%) indicated a willingness to use LA-PrEP versus daily oral PrEP versus no PrEP. Respondents were averse to side effects and increasing costs and preferred increasing levels of protection. Respondents preferred a 2-hour time to obtain LA-PrEP vs 1 hour, with a strong aversion to 3 hours. Overall, there was an aversion to opting out of LA-PrEP, with variations: those with only one partner, no/other insurance or who were Black, Indigenous or People of Colour were significantly less likely to prefer LA-PrEP, while those who were Hispanic/Latino, college educated and cost, clinic time, side effects or protection level; however, preferences varied by sociodemographics. These varied groups likely require tailored intervention strategies to achieve maximum LA-PrEP uptake and persistence.
PubMed ID
38653510
Volume
14
Issue
4
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Recommended Citation
Cole, Sam Wilson; Glick, Jennifer L.; Campoamor, Nicola B.; Sanchez, Travis H.; Sarkar, Supriya; Vannappagari, Vani; Rinehart, Alex; Rawlings, Keith; Sullivan, Patrick S.; and Bridges, John F.P., "Willingness and preferences for long-acting injectable PrEP among US men who have sex with men: a discrete choice experiment" (2024). School of Public Health Faculty Publications. 395.
https://digitalscholar.lsuhsc.edu/soph_facpubs/395
10.1136/bmjopen-2023-083837
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