Document Type
Article
Publication Date
2-27-2024
Publication Title
JCO Clinical Cancer Informatics
Abstract
PURPOSE: Surgical pathology reports are critical for cancer diagnosis and management. To accurately extract information about tumor characteristics from pathology reports in near real time, we explore the impact of using domain-specific transformer models that understand cancer pathology reports. METHODS: We built a pathology transformer model, Path-BigBird, by using 2.7 million pathology reports from six SEER cancer registries. We then compare different variations of Path-BigBird with two less computationally intensive methods: Hierarchical Self-Attention Network (HiSAN) classification model and an off-the-shelf clinical transformer model (Clinical BigBird). We use five pathology information extraction tasks for evaluation: site, subsite, laterality, histology, and behavior. Model performance is evaluated by using macro and micro F1 scores. RESULTS: We found that Path-BigBird and Clinical BigBird outperformed the HiSAN in all tasks. Clinical BigBird performed better on the site and laterality tasks. Versions of the Path-BigBird model performed best on the two most difficult tasks: subsite (micro F1 score of 72.53, macro F1 score of 35.76) and histology (micro F1 score of 80.96, macro F1 score of 37.94). The largest performance gains over the HiSAN model were for histology, for which a Path-BigBird model increased the micro F1 score by 1.44 points and the macro F1 score by 3.55 points. Overall, the results suggest that a Path-BigBird model with a vocabulary derived from well-curated and deidentified data is the best-performing model. CONCLUSION: The Path-BigBird pathology transformer model improves automated information extraction from pathology reports. Although Path-BigBird outperforms Clinical BigBird and HiSAN, these less computationally expensive models still have utility when resources are constrained.
First Page
e2300148
PubMed ID
38412383
Volume
8
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Chandrashekar, Mayanka; Lyngaas, Isaac; Hanson, Heidi A.; Gao, Shang; Wu, Xiao Cheng; and Gounley, John, "Path-BigBird: An AI-Driven Transformer Approach to Classification of Cancer Pathology Reports" (2024). School of Public Health Faculty Publications. 386.
https://digitalscholar.lsuhsc.edu/soph_facpubs/386
10.1200/CCI.23.00148
Included in
Artificial Intelligence and Robotics Commons, Computational Engineering Commons, Epidemiology Commons, Oncology Commons