Association Between Treatment For Localized Prostate Cancer And Mental Health Outcomes
Journal of Urology
Results: A total of 2,742 men (median [quartiles] age 64 [59e70]) met inclusion criteria. Baseline depressive symptoms, as measured by the CES-D, were low (median 4, quartiles 1e8) without differences between groups. We found no effect of treatment modality on depressive symptoms (p[0.78), though older age, poorer health, being unmarried and baseline CES-D score were associated with declines in mental health. There was no clinically meaningful association between treatment modality and scores for either emotional well-being (p[0.81) or energy/fatigue (p[0.054). Conclusions: This prospective, population-based cohort study of men with localized prostate cancer showed no clinically important differences in mental health outcomes including depressive symptoms, emotional well-being, and energy/fatigue according to the treatment received (surgery, radiotherapy, or surveillance). However, we identified a number of characteristics associated with worse mental health outcomes including: older age, poorer health, being unmarried, and baseline CES-D score which may allow for early identification of patients most at risk of these outcomes following treatment.
Luckenbaugh, Amy N.; Wallis, Christopher J.D.; Huang, Li Ching; Wittmann, Daniela; Klaassen, Zachary; Zhao, Zighuo; Koyama, Tatsuki; Laviana, Aaron A.; Conwill, Ralph; Goodman, Michael; Hamilton, Ann S.; Wu, Xiao Cheng; Paddock, Lisa E.; Stroup, Antoinette; Cooperberg, Matthew R.; Hashibe, Mia; O’Neil, Brock B.; Kaplan, Sherrie H.; Greenfield, Sheldon; Hoffman, Karen E.; Penson, David F.; and Barocas, Daniel A., "Association Between Treatment For Localized Prostate Cancer And Mental Health Outcomes" (2022). School of Public Health Faculty Publications. 136.