Practice Patterns and Results of Tumor and Germline Genetic Evaluation of Women With Endometrial Cancer in South Louisiana

Authors

Morgan McDougal, LSU Health Sciences Center- New Orleans
Pallavi Nair-Fairless, LSU Health Sciences Center- New Orleans
Tova Weiss, LSU Health Sciences Center- New Orleans
Elizabeth Dao, LSU Health Sciences Center- New OrleansFollow
Andrew G. Chapple, LSU Health Sciences Center- New OrleansFollow
Amelia Jernigan, LSU Health Sciences Center- New OrleansFollow

Document Type

Article

Publication Date

2-3-2021

Second Department

Biostatistics

Publication Title

Gynecologic Oncology Reports

Abstract

The objectives were to describe rates of MMRd or MSI-H EC tumors, the prevalence of LS, the practice patterns of EC genetic evaluation and adherence to NCCN guidelines, and to identify disparities in the genetic evaluation of women with EC. A retrospective cohort study was performed on women with EC from 1/2013 to 12/2019, and information collected included demographics, personal and family history, EC diagnosis and treatment, and details of genetic evaluation. Statistical analysis included a multivariable logistic regression to adjust for all covariate effects simultaneously and Fisher exact tests of independence and Wilcoxon rank-sum tests to compare categorical and continuous covariates, respectively. Of the 286 women with EC, 80 EC tumors were tested, and 27.5% were MMRd or MSI-H. Of the 21 women who had germline testing, no cases of LS were identified. Before the NCCN recommended universal tumor testing, 17.6% of women had tumor testing performed compared to 60.0% after February of 2017 (OR = 2.51, 95% CI 1.89–3.32). Advanced cancer stage was nearly associated with an increased likelihood of tumor testing (OR = 1.40, 95% CI 1.00–1.97). No disparities were identified. We described patterns of genetic evaluation and tumor testing results for women with EC in south Louisiana and found similar rates of MMRd or MSI-H EC tumors as previously reported in other populations. Rates of tumor testing increased after the NCCN recommendation for universal tumor testing, but it is critical to identify weaknesses in this process and develop an algorithm to improve care for women with EC.

First Page

1

Last Page

6

Volume

36

Publisher

Elsevier

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

McDougal, Morgan; Nair-Fairless, Pallavi; Weiss, Tova; Dao, Elizabeth; Chapple, Andrew G.; and Jernigan, Amelia, "Practice Patterns and Results of Tumor and Germline Genetic Evaluation of Women With Endometrial Cancer in South Louisiana" (2021). School of Nursing Faculty Publications. 5.
https://digitalscholar.lsuhsc.edu/son_facpubs/5

File Format

pdf

File Size

941 KB