Comparative Outcomes of Whole Blood Plus Component Therapy Versus Component Therapy Alone in Hemorrhagic Shock: A Propensity-Matched Analysis
Location
Lions Eye Building
Presentation Date
30-10-2025 11:00 AM
End Date
30-10-2025 1:00 PM
Description
Introduction: Whole blood (WB) transfusion provides red cells, plasma, and platelets in a single product and is increasingly being used in trauma resuscitation. Component therapy (CT) remains the standard, but supplementing CT with WB (CT+WB) may reduce transfusion requirements and improve outcomes. This study compared outcomes of CT+WB versus CT alone in patients with hemorrhagic shock.
Methods: We retrospectively reviewed adult trauma patients with hemorrhagic shock at a Level 1 Trauma Center. Patients received CT+WB or CT alone. Propensity matching (1:2) was performed based on sex, race, age, BMI, mechanism of injury, head AIS, and ISS. Univariable analyses were conducted using chi-square, Mann-Whitney U, and t-tests.
Results: Among 229 patients (85 CT; 144 CT+WB), the cohort was predominantly male (76.4%) and African American (63.7%), with a mean age of 39 years, BMI 26.9, and ISS 21.3. Median transfusion volume was lower in CT+WB (1824 mL, IQR 940–4518; including 1059 mL WB, IQR 545–1127) compared with CT alone (2035 mL, IQR 566–2279). Median length of stay was shorter in CT+WB (7 days, IQR 2–19) versus CT alone (9 days, IQR 5–26; p=0.010). No significant differences were observed in adverse events between groups (p>0.05).
Conclusion: WB supplementation in trauma resuscitation reduces transfusion volume and hospital length of stay without increasing complications. CT+WB represents a viable strategy for managing hemorrhagic shock, particularly when WB supply is limited.
Recommended Citation
Chaisson 2, Jacob, "Comparative Outcomes of Whole Blood Plus Component Therapy Versus Component Therapy Alone in Hemorrhagic Shock: A Propensity-Matched Analysis" (2025). Medical Student Research Poster Symposium. 12.
https://digitalscholar.lsuhsc.edu/sommrd/2025MSRD/session2/12
Abstract
Comparative Outcomes of Whole Blood Plus Component Therapy Versus Component Therapy Alone in Hemorrhagic Shock: A Propensity-Matched Analysis
Lions Eye Building
Introduction: Whole blood (WB) transfusion provides red cells, plasma, and platelets in a single product and is increasingly being used in trauma resuscitation. Component therapy (CT) remains the standard, but supplementing CT with WB (CT+WB) may reduce transfusion requirements and improve outcomes. This study compared outcomes of CT+WB versus CT alone in patients with hemorrhagic shock.
Methods: We retrospectively reviewed adult trauma patients with hemorrhagic shock at a Level 1 Trauma Center. Patients received CT+WB or CT alone. Propensity matching (1:2) was performed based on sex, race, age, BMI, mechanism of injury, head AIS, and ISS. Univariable analyses were conducted using chi-square, Mann-Whitney U, and t-tests.
Results: Among 229 patients (85 CT; 144 CT+WB), the cohort was predominantly male (76.4%) and African American (63.7%), with a mean age of 39 years, BMI 26.9, and ISS 21.3. Median transfusion volume was lower in CT+WB (1824 mL, IQR 940–4518; including 1059 mL WB, IQR 545–1127) compared with CT alone (2035 mL, IQR 566–2279). Median length of stay was shorter in CT+WB (7 days, IQR 2–19) versus CT alone (9 days, IQR 5–26; p=0.010). No significant differences were observed in adverse events between groups (p>0.05).
Conclusion: WB supplementation in trauma resuscitation reduces transfusion volume and hospital length of stay without increasing complications. CT+WB represents a viable strategy for managing hemorrhagic shock, particularly when WB supply is limited.
Comments
Mentor: Dr. Alison Smith, LSUHSC-Department of Surgery