The Progression of Anal Intraepithelial Neoplasia in HIV+ Patients
Location
Medical Education Building, LSUHSC-NO
Presentation Date
10-10-2019 10:00 AM
End Date
10-10-2019 12:00 PM
Description
Anal squamous cell carcinoma, a rare type of cancer, affects HIV positive individuals at a particularly high rate, and it develops from Anal Intraepithelial Neoplasia (AIN). Anal Intraepithelial Neoplasia can be classified as low-grade or high-grade, and it is thought that low-grade lesions progress to high-grade lesions, which can then progress to anal carcinomas. This longitudinal study examines the progression of high-grade squamous intraepithelial lesions (HSIL) over time. The goal of this research is to determine the most effective approach in preventing anal cancer development from high-grade squamous epithelial lesions. Progression of HSIL is tracked in patients whose lesions are closely observed and monitored and in patients whose lesions are treated. Treatment methods include hyfrecation, efudex, and surgical ablation. Anal pap smear and biopsy data is collected from participants in the Anal Cancer/HSIL Outcomes Research (ANCHOR) study. From the biopsy data collected thus far, it was determined that high-grade lesions improved in 76% of subjects in the treatment arm, compared to improvement in only 35% of subjects in the active monitoring arm. When individual lesions were examined, it was determined that 69% of treated lesions improved, compared to 29% of lesions that were monitored. Additional data collection and analysis is ongoing.
Recommended Citation
Talbot, Annie C., "The Progression of Anal Intraepithelial Neoplasia in HIV+ Patients" (2019). Medical Student Research Poster Symposium. 39.
https://digitalscholar.lsuhsc.edu/sommrd/2019/posters/39
The Progression of Anal Intraepithelial Neoplasia in HIV+ Patients
Medical Education Building, LSUHSC-NO
Anal squamous cell carcinoma, a rare type of cancer, affects HIV positive individuals at a particularly high rate, and it develops from Anal Intraepithelial Neoplasia (AIN). Anal Intraepithelial Neoplasia can be classified as low-grade or high-grade, and it is thought that low-grade lesions progress to high-grade lesions, which can then progress to anal carcinomas. This longitudinal study examines the progression of high-grade squamous intraepithelial lesions (HSIL) over time. The goal of this research is to determine the most effective approach in preventing anal cancer development from high-grade squamous epithelial lesions. Progression of HSIL is tracked in patients whose lesions are closely observed and monitored and in patients whose lesions are treated. Treatment methods include hyfrecation, efudex, and surgical ablation. Anal pap smear and biopsy data is collected from participants in the Anal Cancer/HSIL Outcomes Research (ANCHOR) study. From the biopsy data collected thus far, it was determined that high-grade lesions improved in 76% of subjects in the treatment arm, compared to improvement in only 35% of subjects in the active monitoring arm. When individual lesions were examined, it was determined that 69% of treated lesions improved, compared to 29% of lesions that were monitored. Additional data collection and analysis is ongoing.
Comments
Mentor: Michael Hagensee, MD, PhD (Department of Medicine and Microbiology)