A Case Of Refractory Angioedema

Authors

Thomas M. Irwin, University of Kansas Cancer Center
Thomas M. Irwin, ENT of New Orleans
Andrew Longanecker, LSU Health Sciences Center - New OrleansFollow
William Spence Bodenhamer, University of Kansas, School of Medicine
Carla C. Keirns, University of Kansas, School of Medicine

Document Type

Article

Publication Date

12-13-2022

Publication Title

Journal of Intensive Care Medicine

Abstract

Angioedema is an acute disorder that affects mucous membranes and the deepest layers of the skin along with underlying tissue, marked by rapid swelling, large welts, and pain. There are 3 major subtypes of angioedema: mast-cell mediated, bradykinin-mediated, and multifactorial or unclear mechanism subtype. The most common subtype of bradykinin-mediated angioedema is ACE-inhibitor induced, which disproportionately affects African-Americans. It is most often self-limiting and usually responds to the withdrawal of the offending agent. The prolonged duration of angioedema is uncommon in the absence of a persistent stimulus, though it is more likely when there is an abnormality of the metabolic pathways, such as in hereditary angioedema or other gene polymorphisms affecting the complement system. We present a case of severe angioedema that persisted for over a month and required a tracheostomy to manage the airway.

First Page

313

Last Page

320

PubMed ID

36514293

Volume

38

Issue

3

Recommended Citation

Irwin, Thomas M.; Irwin, Thomas M.; Longanecker, Andrew; Bodenhamer, William Spence; and Keirns, Carla C., "A Case Of Refractory Angioedema" (2022). School of Medicine Faculty Publications. 985.
https://digitalscholar.lsuhsc.edu/som_facpubs/985
10.1177/08850666221145310