Procedural Outcomes Of Pulmonary Atresia With Intact Ventricular Septum In Neonates: A Multicenter Study
Document Type
Article
Publication Date
6-1-2023
Publication Title
Annals of Thoracic Surgery
Abstract
Background: Multicenter contemporary data describing short-term outcomes after initial interventions of neonates with pulmonary atresia with intact ventricular septum (PA-IVS) are limited. This multicenter study describes characteristics and outcomes of PA-IVS neonates after their initial catheter or surgical intervention and identifies factors associated with major adverse cardiac events (MACE). Methods: Neonates with PA-IVS who underwent surgical or catheter intervention between 2009 and 2019 in 19 centers were reviewed. Risk factors for MACE, defined as cardiopulmonary resuscitation, mechanical circulatory support, stroke, or in-hospital mortality, were analyzed using multivariable logistic regression models. Results: We reviewed 279 neonates: 79 (28%) underwent right ventricular decompression, 151 (54%) underwent systemic-to-pulmonary shunt or ductal stent placement only, 36 (13%) underwent right ventricular decompression with shunt or ductal stent placement, and 11 (4%) underwent transplantation. MACE occurred in 57 patients (20%): 26 (9%) received mechanical circulatory support, 37 (13%) received cardiopulmonary resuscitation, stroke occurred in 16 (6%), and 23 (8%) died. The presence of 2 major coronary artery stenoses (adjusted odds ratio, 4.99; 95% CI, 1.16-21.39) and lower weight at first intervention (adjusted odds ratio, 1.52; 95% CI, 1.01-2.27) were significantly associated with MACE. Coronary ischemia was the most frequent presumed mechanism of death (n = 10). Conclusions: In a multicenter cohort, 1 in 5 neonates with PA-IVS experienced MACE after their initial intervention. Patients with 2 major coronary artery stenoses or lower weight at the time of the initial procedure were most likely to experience MACE and warrant vigilance during preintervention planning and postintervention management.
First Page
1470
Last Page
1477
PubMed ID
36070807
Volume
115
Issue
6
Recommended Citation
Cheung, Eva W.; Mastropietro, Christopher W.; Flores, Saul; Amula, Venugopal; Radman, Monique; Kwiatkowski, David; Puente, Bao Nguyen; Buckley, Jason R.; Allen, Kiona; Loomba, Rohit; Karki, Karan; Chiwane, Saurabh; Cashen, Katherine; Piggott, Kurt; Kapileshwarkar, Yamini; Gowda, Keshava Murthy Narayana; Badheka, Aditya; Raman, Rahul; Costello, John M.; Zang, Huaiyu; and Iliopoulos, Ilias, "Procedural Outcomes Of Pulmonary Atresia With Intact Ventricular Septum In Neonates: A Multicenter Study" (2023). School of Medicine Faculty Publications. 958.
https://digitalscholar.lsuhsc.edu/som_facpubs/958