Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics

Document Type

Book Chapter

Publication Date

3-3-2023

Editor

Alan David Kaye; Elyse M. Cornett

Abstract

Clinical trials explore group interventions and are used to determine the safety, effectiveness, and risk–benefit ratio of therapies. Clinical trial planning involves several structural designs. Single-arm, placebo-controlled, crossover, factorial, noninferiority, and diagnostic device validation designs are common ones. Meaningful research requires effective data collecting. Researchers must collect enough data to draw conclusions without overburdening participants and personnel. Primary, secondary, and nonoutcome data may be collected. After deciding what data to collect, researchers must choose a technique. Surveys, interviews, and examinations collect data. All have pros and cons, thus they must be employed based on the experiment.

First Page

55

Last Page

64

Chapter Title

Chapter 5 - Experimental design in clinical trials

Publisher

Elsevier

ISBN

9780323988148

Link to Full Text

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