Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics

Document Type

Book Chapter

Publication Date

3-3-2023

Editor

Alan David Kaye; Elyse M. Cornett

Abstract

Substance misuse is a significant health and social issue. At present, it is known that epigenetic factors contribute significantly to susceptibility to various drug use disorders. It is important to consider these potential variables to provide the most effective and efficient treatments, especially pain treatment, in patients who present for clinical management. The present investigation reviews in detail the pharmacogenetics and metabolism of opioids, nicotine, and alcohol use, postanesthesia problems, and highlights recent studies.

First Page

333

Last Page

347

Chapter Title

Chapter 24 - Pharmacogenetics: a comprehensive review of genes, genetics, genomics, and epigenetics

Publisher

Elsevier

ISBN

9780323988148

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