Autoimmune Myelofibrosis in a 12-Year-old Male with Monosomy 7, Systemic Lupus Erythematous and Lupus Nephritis: A Case Report and Review of the Literature
Document Type
Article
Publication Date
1-1-2023
Publication Title
Journal of Pediatric Hematology/Oncology
Abstract
Complete or partial loss of chromosome 7 is a common and well-known cytogenetic abnormality associated with preleukemic myelodysplasia and myeloid leukemia but not with autoimmune myelofibrosis. Detection of this molecular change represents poor prognosis. When malignant transformation occurs, the condition tends to be chemotherapy-resistant requiring haematopoietic stem cell transplantation (HSCT) to obtain a cure. Disappearance after immunosuppressive therapy has been documented in children with hematological disorders but not in association with cyclophosphamide and systemic lupus erythematous.We present the interesting case of a 12-year-old male with monosomy 7, systemic lupus erythematous, and lupus nephritis with the resolution of the monosomy 7 and autoimmune myelofibrosis after treatment with cyclophosphamide, along with a review of the literature.
First Page
E1
Last Page
E3
PubMed ID
35973025
Volume
45
Issue
1
Recommended Citation
Español, María G.; Ehlayel, Abdulla M.; Alicea Marrero, Minelys M.; Gardner, Renee V.; and Velez, María C., "Autoimmune Myelofibrosis in a 12-Year-old Male with Monosomy 7, Systemic Lupus Erythematous and Lupus Nephritis: A Case Report and Review of the Literature" (2023). School of Medicine Faculty Publications. 529.
https://digitalscholar.lsuhsc.edu/som_facpubs/529
10.1097/MPH.0000000000002523