Attrition and Delays in Kidney Transplant Evaluation Among People Living With HIV and End-Stage Renal Disease
Document Type
Article
Publication Date
8-13-2026
Publication Title
Transplant Infectious Disease
Abstract
INTRODUCTION: People living with HIV (PLWH) have a higher incidence of end-stage renal disease (ESRD) than HIV-negative individuals and are less likely to receive a kidney transplant. We described attrition and delays across the transplant care continuum for PLWH with ESRD at the Medical University of South Carolina (MUSC) and explored factors associated with waitlisting.
METHODS: Retrospective review of electronic health records of PLWH with ESRD who received care at MUSC or were referred for kidney transplantation between May 1, 2012 and December 31, 2023. Progression through the transplant continuum (referral, evaluation initiation, evaluation completion, waitlisting, and transplantation) was quantified. Multivariable time-to-event analyses was performed.
RESULTS: Among 234 PLWH with ESRD, transplant referral occurred in 190 (80%), of whom 135 (71%) initiated evaluation, 75 (39%) completed evaluation, 62 (32%) were waitlisted, and 44 (23%) received a transplant. Among evaluation non-completers, outstanding testing (42%) and excessive comorbidities (15%) were the most common reasons. Median time from dialysis to referral was 510 days (IQR 139-1665), and median time from evaluation to waitlisting was 306 days (IQR 186-520). In multivariable Cox regression, peritoneal dialysis was associated with shorter time to waitlisting (HR 2.60; 95% CI 1.17-5.75; p = 0.02) and Black race trended towards longer time to waitlisting (HR 0.30; 95% CI 0.08-1.11; p = 0.07).
CONCLUSIONS: Although PLWH with ESRD at MUSC progressed through the transplant continuum, substantial delays were observed. Interventions to reduce structural and logistical barriers and streamline evaluation steps may improve timely access to kidney transplantation.
First Page
1
Last Page
9
PubMed ID
42596058
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Crawford, Kyle M.; Catalano, Jillian; Shah, Dhriti; Curry, Scott; Mills, Alexandra G.; Alkabab, Yosra; Charles, Drew; Harris, Courtney E.; and Adekunle, Ruth O., "Attrition and Delays in Kidney Transplant Evaluation Among People Living With HIV and End-Stage Renal Disease" (2026). School of Medicine Faculty Publications. 5240.
https://digitalscholar.lsuhsc.edu/som_facpubs/5240
10.1111/tid.70304