Specific Antibody Deficiencies

Authors

• Luke A. Wall, LSU Health Sciences Center - New OrleansFollow
• Victoria R. Dimitriades, LSU Health Sciences Center - New Orleans
• Ricardo U. Sorensen, LSU Health Sciences Center - New OrleansFollow

Document Type

Article

Publication Date

10-8-2015

Publication Title

Immunology and Allergy Clinics of North America

Abstract

Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptoms. Most patients have a good prognosis. The deficiency may resolve over time, especially in children.

First Page

659

Last Page

670

PubMed ID

26454312

Volume

35

Issue

4

Publisher

Elsevier

Rights

Copyright © 2015 Elsevier Inc.

Recommended Citation

Wall, Luke A.; Dimitriades, Victoria R.; and Sorensen, Ricardo U., "Specific Antibody Deficiencies" (2015). School of Medicine Faculty Publications. 5208.
https://digitalscholar.lsuhsc.edu/som_facpubs/5208
10.1016/j.iac.2015.07.003