Advancing the Study of Glioblastoma Through 3D Tumor Models

Authors

• K.M. Salmeron-Moreno, Emory University, Atlanta, GA
• J. Buclez, Emory University, Atlanta, GA
• C. Donghyun Kim, Emory University, Atlanta, GA
• K. Papisetty, Emory University, Atlanta, GA
• T. McCaffery, Emory University, Atlanta, GA
• F. Jacob, Emory University, Atlanta, GA
• R. Kashlan, Emory University, Atlanta, GA
• H. Duggireddy, Emory University, Atlanta, GA
• K. Valiveti, Emory University, Atlanta, GA
• Justin Maldonado, LSU Health Sciences Center - New Orleans
• G. Pradilla, Emory University, Atlanta, GA
• T. Garzon-Muvdi, Emory University, Atlanta, GA

Document Type

Article

Publication Date

2-18-2026

Publication Title

Cancers

Abstract

Glioblastoma (GBM), the most aggressive primary brain malignancy, remains a challenge to experimentally model. Accurately modeling the intra- and intertumoral heterogeneity of GBMs is essential for enhancing the predictive power of preclinical models and improving the effectiveness of current therapies. This review highlights recent advances in 3D tumor modeling, which accurately replicate the structural, cellular, and biochemical complexity of GBMs. We examine their translational potential and discuss current barriers to clinical translation.

Volume

18

Issue

4

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Recommended Citation

Salmeron-Moreno, K.M.; Buclez, J.; Donghyun Kim, C.; Papisetty, K.; McCaffery, T.; Jacob, F.; Kashlan, R.; Duggireddy, H.; Valiveti, K.; Maldonado, Justin; Pradilla, G.; and Garzon-Muvdi, T., "Advancing the Study of Glioblastoma Through 3D Tumor Models" (2026). School of Medicine Faculty Publications. 5199.
https://digitalscholar.lsuhsc.edu/som_facpubs/5199
10.3390/cancers18040668