Newborn screening reduces survival disparities in SCID after stem cell transplant: A PIDTC report

Authors

• Lena E. Winestone, University of California, San Francisco, CA
• Brent R. Logan, Medical College of Wisconsin, Milwaukee, WI
• Xuerong Liu, Medical College of Wisconsin, Milwaukee, WI
• Olatundun Williams, Fred Hutchinson Cancer Center, Seattle, WA
• Elizabeth A. Dunn, University of California, San Francisco, CA
• Monica S. Thakar, Fred Hutchinson Cancer Center, Seattle, WA
• Sharon A. Kidd, University of California, San Francisco, CA
• Talal Mousallem, Duke University School of Medicine, Durham, NC
• Morna J. Dorsey, University of California, San Francisco, CA
• Richard J. O'Reilly, Memorial Sloan Kettering Cancer Center, New York, NY
• Neena Kapoor, University of Southern California, Los Angeles, CA
• Lisa Forbes Satter, Baylor College of Medicine, Houston, TX
• Malika Kapadia, Harvard University Medical School, Boston, MA
• Soma C. Jyonouchi, Children's Hospital of Philadelphia, Philadelphia, PA
• Sharat Chandra, University of Cincinnati College of Medicine, Cincinnati, OH
• Christen L. Ebens, University of Minnesota, Minneapolis, MN
• Deepakbabu Chellapandian, Johns Hopkins All Children's Hospital, St. Petersburg, FL
• Sonali Chaudhury, Northwestern University Feinberg School of Medicine, Chicago, IL
• Karin Chen, University of Washington, Seattle, WA
• Blachy J. Dávila Saldaña, George Washington University School of Medicine and Health Sciences, Washington, DC
• Ahmad Rayes, University of Utah, Salt Lake City, UT
• Troy C. Quigg, Michigan State University College of Human Medicine, Grand Rapids, MI
• Shanmuganathan Chandrakasan, Emory University School of Medicine, Atlanta, GA
• Jeffrey J. Bednarski, Washington University School of Medicine, St. Louis, MO
• Kenneth B. DeSantes, University of Madison-Wisconsin, Madison, WI
• Pierre Teira, University of Montreal, Montreal, Quebec, Canada
• Alfred P. Gillio, Hackensack University Medical Center, Hackensack, NJ
• Hesham Eissa, University of Colorado, Aurora, CO
• Lolie C. Yu, LSU Health Sciences Center – New OrleansFollow
• et al

Document Type

Article

Publication Date

7-7-2026

Publication Title

Journal of Human Immunity

Abstract

Black race and Hispanic ethnicity are associated with higher mortality in severe combined immunodeficiency (SCID) following hematopoietic cell transplantation (HCT), though mechanisms remain unclear. We evaluated 796 children with SCID who received nonsibling HCT between 1982 and 2020 using data from the Primary Immune Deficiency Treatment Consortium. Overall survival for Black (aHR 2.47, 95%CI 1.64, 3.71) and Asian/Pacific Islander patients (aHR 1.82, 95%CI 1.00, 3.30) was significantly lower compared with non-Hispanic White patients, while Hispanic patients had lower event-free survival (aHR 1.83, 95%CI 1.27, 2.63) compared with non-Hispanic White patients. Even after adjusting for age and infection, Black patients with SCID had more than twofold hazard of death compared with non-Hispanic White patients. NBS was associated with earlier diagnosis, reduced infection at HCT, and elimination of survival disparities between Black and non-Hispanic White patients. These findings suggest that universal, system-level interventions such as NBS can mitigate disparities in outcomes for children with SCID.

First Page

e20250231

PubMed ID

42416786

Volume

2

Issue

5

Comments

See article for full author list.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Winestone, Lena E.; Logan, Brent R.; Liu, Xuerong; Williams, Olatundun; Dunn, Elizabeth A.; Thakar, Monica S.; Kidd, Sharon A.; Mousallem, Talal; Dorsey, Morna J.; O'Reilly, Richard J.; Kapoor, Neena; Forbes Satter, Lisa; Kapadia, Malika; Jyonouchi, Soma C.; Chandra, Sharat; Ebens, Christen L.; Chellapandian, Deepakbabu; Chaudhury, Sonali; Chen, Karin; Dávila Saldaña, Blachy J.; Rayes, Ahmad; Quigg, Troy C.; Chandrakasan, Shanmuganathan; Bednarski, Jeffrey J.; DeSantes, Kenneth B.; Teira, Pierre; Gillio, Alfred P.; Eissa, Hesham; Yu, Lolie C.; and al, et, "Newborn screening reduces survival disparities in SCID after stem cell transplant: A PIDTC report" (2026). School of Medicine Faculty Publications. 5007.
https://digitalscholar.lsuhsc.edu/som_facpubs/5007
10.70962/jhi.20250231