Cerebriform Nevus Sebaceous in a Newborn: Answer

Document Type

Article

Publication Date

9-1-2026

Publication Title

American Journal of Dermatopathology

Abstract

Nevus sebaceous is a congenital organoid hamartoma of the pilosebaceous unit and is considered part of a spectrum of epidermal nevi arising from postzygotic genetic mosaicism. Activating mutations in HRAS or KRAS have been identified in lesional keratinocytes, leading to constitutive activation of downstream signaling pathways, including the MAPK and PI3K pathways, and resulting in abnormal adnexal proliferation.

First Page

739

Last Page

740

PubMed ID

42617088

Volume

48

Issue

9

Rights

Copyright © 2026, Wolters Kluwer Health

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