Adrenal Carcinoma Laterality is of Limited Clinical Significance: A National Perspective

Authors

• Mohammad H. Hussein, Ochsner Clinic Foundation, New Orleans, LA
• Peter P. Issa, LSU Health Sciences Center - New OrleansFollow
• Tessa R. Lavorgna, Tulane University, New Orleans, LA
• Chad P. Issa, LSU Health Sciences Center - New OrleansFollow
• Charlotte Pecot, Tulane University, New Orleans, LA
• Manal S. Fawzy, Northern Border University, Arar, Saudi Arabia
• Eman A. Toraih, Upstate Medical University, New York, NY

Document Type

Article

Publication Date

6-19-2026

Publication Title

Cancer Investigation

Abstract

The clinical implication of adrenal cancer laterality is not well investigated. This retrospective study used the National Cancer Database, including 3962 patients with primary adrenal malignancies. Similar analyses of patients with adrenal cancer were retrieved from the cBioPortal/The Cancer Genome Atlas to validate our findings. Left-sidedness was associated with larger tumor size and distant metastasis, while right-sided tumors displayed LN metastasis more often. There was no difference in survival between the two groups. Analysis of differential genomic and transcriptomic/proteomic effects between right/left adrenal carcinomas was found to be similar. Our analysis highlighted the limited clinical importance of adrenal carcinoma laterality.

First Page

1

Last Page

11

PubMed ID

42318686

Rights

©2026 Taylor & Francis Group, LLC

Recommended Citation

Hussein, Mohammad H.; Issa, Peter P.; Lavorgna, Tessa R.; Issa, Chad P.; Pecot, Charlotte; Fawzy, Manal S.; and Toraih, Eman A., "Adrenal Carcinoma Laterality is of Limited Clinical Significance: A National Perspective" (2026). School of Medicine Faculty Publications. 4916.
https://digitalscholar.lsuhsc.edu/som_facpubs/4916
10.1080/07357907.2026.2675647