High-Grade Small Bowel Dysplasia Following Prior Adenocarcinoma in Small Bowel Crohn's Disease

Authors

• Farhan S. Mohiuddin, LSU Health Sciences Center - New OrleansFollow
• Laine Lyles, LSU Health Sciences Center - New OrleansFollow
• Nisha Loganantharaj, LSU Health Sciences Center - New OrleansFollow

Document Type

Article

Publication Date

4-2-2026

Publication Title

Cureus

Abstract

Patients with Crohn's disease are at increased risk of small bowel adenocarcinoma due to chronic inflammation, though absolute incidence is low and surveillance guidelines are unclear. We report a patient with long-standing small bowel Crohn's disease and prior adenocarcinoma who developed high-grade dysplasia despite clinical, biochemical, and endoscopic remission on biologic therapy. An asymptomatic rise in fecal calprotectin prompted imaging and device-assisted enteroscopy, revealing a non-traversable stricture. Surgical resection confirmed high-grade dysplasia with negative margins. This case underscores persistent malignancy risk in fibrostenosing Crohn's disease and the importance of biomarkers and advanced diagnostics in high-risk patients.

First Page

1

Last Page

4

PubMed ID

42078267

Volume

18

Issue

4

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Mohiuddin, Farhan S.; Lyles, Laine; and Loganantharaj, Nisha, "High-Grade Small Bowel Dysplasia Following Prior Adenocarcinoma in Small Bowel Crohn's Disease" (2026). School of Medicine Faculty Publications. 4743.
https://digitalscholar.lsuhsc.edu/som_facpubs/4743
10.7759/cureus.106330