The Impact of Hepatitis C on Complication Rates After Revision Total Knee Arthroplasty: A Matched Cohort Study

Authors

• Bailey J. Ross, Emory University School of Medicine, Atlanta, GA
• Austin J. Ross, Tulane University School of Medicine, New Orleans, LA
• Matthew W. Cole, Tulane University School of Medicine, New Orleans, LA
• George N. Guild, Emory University School of Medicine, Atlanta, GA
• Olivia C. Lee, LSU Health Sciences Center - New OrleansFollow
• William F. Sherman, Tulane University School of Medicine, New Orleans, LA

Document Type

Article

Publication Date

10-22-2022

Publication Title

Arthroplasty Today

Abstract

Background: It is unclear if hepatitis C (HCV) negatively impacts outcomes of revision total knee arthroplasty (rTKA). The purpose of this study was to compare complication rates after rTKA for patients with HCV vs matched controls. Methods: A retrospective cohort study was conducted using the PearlDiver database (PearlDiver Inc., Colorado Springs, CO). Patients with HCV who underwent rTKA (n = 1448) were matched 1:4 with controls (n = 5792) on age, sex, and several comorbidities. Rates of medical complications within 90 days and prothesis-related complications within 2 years postoperatively were compared with logistic regression for (1) patients with vs without HCV and (2) HCV patients who underwent aseptic vs septic rTKA. Results: Relative to controls, patients with HCV exhibited significantly higher rates of medical complications (27.7% vs 20.9%; odds ratio [OR] 1.47), periprosthetic fractures (2.3% vs 1.1%; OR 2.20), all-cause repeat rTKA (11.7% vs 9.4%; OR 1.29), and repeat rTKA for prosthetic joint infection (PJI) (6.7% vs 3.6%; OR 1.92). Within the HCV cohort, HCV patients with initial septic rTKA exhibited significantly higher rates of medical complications (41.7% vs 22.7%; OR 2.39), all-cause subsequent rTKA (15.9% vs 10.2%; OR 1.67), and repeat rTKA for PJI (15.9% vs 3.4%; OR 5.39). Conversely, HCV patients with initial aseptic rTKA exhibited significantly higher rates of aseptic loosening (2.6% vs 7.4%; OR 0.33). Conclusions: Patients with HCV exhibited significantly higher rates of medical and prosthesis-related complications after rTKA than controls. Among patients with HCV, initial septic rTKA was associated with significantly higher rates of medical complications, repeat rTKA, and PJI.

First Page

212

Last Page

218.e2

PubMed ID

36561550

Volume

18

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Ross, Bailey J.; Ross, Austin J.; Cole, Matthew W.; Guild, George N.; Lee, Olivia C.; and Sherman, William F., "The Impact of Hepatitis C on Complication Rates After Revision Total Knee Arthroplasty: A Matched Cohort Study" (2022). School of Medicine Faculty Publications. 4632.
https://digitalscholar.lsuhsc.edu/som_facpubs/4632
10.1016/j.artd.2022.09.010