Addressing conceptual and design gaps in the oncology nutrition evidence base during chemotherapy: contributions of the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes Consortium

Document Type

Article

Publication Date

6-18-2025

Publication Title

Journal of the National Cancer Institute

Abstract

Evidence to support the development of practice guidelines on nutrition interventions during active cancer treatment is limited despite the established role of nutrition in cancer prevention and long-term survivorship. To address this gap, the National Cancer Institute funded the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes (ENICTO) research consortium. This manuscript focuses on the nutrition-specific work within the ENICTO Consortium. We present a conceptual framework describing how nutritional interventions may enhance cancer treatment tolerance and timely completion of chemotherapy. We also describe how each ENICTO research project selected specific nutrition-related data items and collection methods to test hypotheses outlined in the conceptual framework. Research and consortium-wide projects are described in relation to advancing the scientific rigor of research in the field, including the standardization of nutrition assessment tools and measures. We conclude with a call to action for further research to support the development of evidence-based oncology nutrition practice guidelines relevant to the treatment period within the cancer continuum.

First Page

2441

Last Page

2451

PubMed ID

40680173

Volume

117

Issue

12

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Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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