Document Type

Article

Publication Date

10-8-2025

Publication Title

Cureus

Abstract

Granuloma annulare (GA) is a benign, non-infectious granulomatous skin condition of uncertain etiology, often presenting as annular erythematous plaques. While commonly localized to the hands and feet, GA has multiple clinical variants and can mimic other dermatologic conditions, leading to diagnostic challenges. We report a rare case of GA localized to the inguinal region in a 55-year-old female initially treated empirically for candidal intertrigo without improvement. Biopsy demonstrated interstitial histiocytic infiltrates dissecting between collagen bundles with increased dermal mucin, confirming a diagnosis of interstitial GA. The patient was subsequently treated with triamcinolone 0.1% ointment and hydroxychloroquine 200 mg twice daily and is currently pending follow-up. While GA often resolves spontaneously, refractory cases require individualized management, as no gold-standard therapy exists. The objective of this report is to highlight an atypical presentation of GA and emphasize the importance of maintaining a broad differential diagnosis for annular skin lesions. Further research is needed to elucidate GA's pathogenesis and optimize treatment strategies for chronic or widespread disease.

First Page

e94157

PubMed ID

41210045

Volume

17

Issue

10

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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