Dupuytren's Disease: Current and Emerging Techniques

Document Type

Book Chapter

Publication Date

4-27-2025

Abstract

Dupuytren’s disease (DD) is a fibroproliferative disorder that affects the palmar aponeurosis and causes flexure contractures of the digits. Treatment is typically advised with flexion contracture of at least 30 degrees at the metacarpophalangeal (MCP) or proximal interphalangeal (PIP) joints [1]. Surgical excision of the diseased tissue has been the gold standard treatment [2]. However, surgery can be costly with potential for wound breakdown, infection, recurrence, and risk for neurovascular injury. Thus, nonsurgical options have been explored that can be implemented in an office-based setting, decrease morbidity, decrease cost and recovery time, but still improve function and quality of life [3]. Collagenase Clostridium histolyticum (CCH) injections have become a popular nonsurgical treatment option that have shown excellent outcomes in properly selected patients [4]. Xiaflex[[sup]]®[[/sup]], a commercial CCH specifically designed for medical purposes, was FDA approved in 2010 and has clear guidelines for appropriate use to optimize benefits and reduce risks.

First Page

51

Last Page

61

Chapter Title

Chapter 5 - Collagenase Injections: Background and Technique

Publisher

Springer Nature

ISBN

[9783031858727, 9783031858734]

Rights

© 2025 The Author(s), under exclusive license to Springer Nature Switzerland AG

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