Peritoneal Metastases in Gastrointestinal Malignancies: A Review of the Pathophysiology of Metastasis and the Tumour Microenvironment

Authors

Milee Patel, Tulane University, New Orleans, LA
Kristen Limbach, Tulane University, New Orleans, LA
Elizabeth Martin, Tulane University, New Orleans, LA
Matthew Burow, Tulane University, New Orleans, LA
Kevin M. Sullivan, LSU Health Sciences Center - New OrleansFollow

Document Type

Article

Publication Date

9-29-2025

Publication Title

Journal of Surgical Oncology

Abstract

Peritoneal metastasis is a significant source of morbidity and mortality for patients with cancer from gastrointestinal origin such as gastric, colorectal, and appendiceal cancers, and treatment options are limited. Cross-sectional imaging is limited in sensitivity and specificity, and treating peritoneal metastases is limited by the bioavailability of systemic cytotoxic chemotherapy and metastatic burden. Within this review, we specifically explore the pathophysiology underlying peritoneal metastasis while emphasising the contributions of the tumour microenvironment and immune system.

First Page

1190

Last Page

1196

PubMed ID

41020438

Issue

7

Rights

© Wiley Periodicals LLC

Recommended Citation

Patel, Milee; Limbach, Kristen; Martin, Elizabeth; Burow, Matthew; and Sullivan, Kevin M., "Peritoneal Metastases in Gastrointestinal Malignancies: A Review of the Pathophysiology of Metastasis and the Tumour Microenvironment" (2025). School of Medicine Faculty Publications. 4175.
https://digitalscholar.lsuhsc.edu/som_facpubs/4175
10.1002/jso.70090