Document Type
Article
Publication Date
8-12-2025
Publication Title
Clinics and Practice
Abstract
Attention Deficit Hyperactivity Disorder (ADHD) is a lifelong condition; however, traditional treatment focuses on hyperactivity and inattention, which is largely a manifestation of pediatric ADHD. Studies are limited regarding cognitive difficulties, as seen in adult ADHD, as well as treatment strategies for this population. This review of the literature examines multiple recent studies that discuss various novel treatment strategies for cognitive impairment in adults with ADHD. A targeted literature review was conducted using PubMed to identify recent studies on cognitive dysfunction in adults with ADHD, with an emphasis on emerging treatment strategies. Data collected included sample size, intervention strategies, cognitive function, and side effects. Studies on non-invasive brain stimulation revealed significant effects on executive function in adult ADHD patients. Other studies revealed statistically significant improvements in cognitive flexibility and response inhibition in modafinil users. Another study demonstrated significant improvement in working memory with off label use of viloxazine for adults. This review of the literature describes the effectiveness of novel treatment strategies of adult ADHD including non-stimulant medications, behavioral therapies and neurofeedback. This highlights the need for treatment modalities that enhance cognitive outcomes and further research into long-term efficacy and safety of these novel interventions and implementing psychological treatment into medical management of adult ADHD.
PubMed ID
40863101
Volume
15
Issue
8
Publisher
MDPI
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Vega, Alexis J.; Hernandez, Gabriel V.; Anwar, Ahmed I.; Sharafi, Bahareh; Islam, Rahib K.; Shekoohi, Sahar; and Kaye, Alan D., "Cognitive Impairment in Adult Attention Deficit Hyperactivity Disorder: Clinical Implications and Novel Treatment Strategies" (2025). School of Medicine Faculty Publications. 4014.
https://digitalscholar.lsuhsc.edu/som_facpubs/4014
10.3390/clinpract15080150
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Mental Disorders Commons, Psychiatric and Mental Health Commons, Psychoanalysis and Psychotherapy Commons, Psychological Phenomena and Processes Commons, Therapeutics Commons