Insights Into Kaposi Sarcoma-Associated Herpesvirus-Specific Humoral Responses

Document Type

Article

Publication Date

9-8-2025

Publication Title

Journal of Medical Virology

Abstract

Kaposi sarcoma (KS) remains a global health concern. In sub-Saharan Africa, where there is a high burden of HIV-1 infection, there is also a high prevalence of infection by the etiologic agent of KS, the KS-associated herpesvirus (KSHV). Despite the successes of antiretroviral treatment (ART), the burden of KS and other KSHV-associated malignancies among people living with HIV under ART remained high, stressing the need for a greater understanding of the immune response against KSHV infection. Here, we review the current information on KSHV-specific humoral response in infected individuals in detail. We discuss the significance of anti-KSHV responses, mechanisms used by KSHV to subvert and modulate humoral immunity, and implications for pathogenesis and therapy. We highlight cutting-edge serological assays and bioinformatics tools that aid the development of effective vaccines against KSHV, underscoring the complexity of the humoral response and its critical role within the context of infection and vaccine design.

PubMed ID

40916576

Volume

97

Issue

9

Publisher

Wiley

Rights

© 1999-2025 John Wiley & Sons, Inc or related companies. All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies.

Link to Full Text

Share

COinS