Document Type
Article
Publication Date
1-1-2025
Publication Title
Frontiers in pediatrics
Abstract
Neonatal herpes simplex virus (HSV) infection carries a high mortality rate due to its potential to cause disseminated disease involving multiple organ systems, which can rapidly progress to shock and death if not promptly treated. In rare cases, neonates may mount an uncontrolled inflammatory response leading to hemophagocytic lymphohistiocytosis (HLH), a severe hyperinflammatory syndrome. We present a case of neonatal HSV infection complicated by HLH, highlighting the challenges of managing both conditions concurrently. Our therapeutic approach demonstrated a reduction in systemic inflammation and viral load; however, despite these efforts, the patient developed multiorgan failure and ultimately died from the initial disease process. This case underscores the severity of neonatal HSV infection and emphasizes the critical role pediatricians play in early identification of transmission risk factors and prevention strategies.
First Page
1571715
PubMed ID
40755917
Volume
13
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Tadros, Nicholas and Godiwala, Nihal, "Case Report: Disseminated herpes simplex virus complicated by hemophagocytic lymphohistiocytosis in a neonate" (2025). School of Medicine Faculty Publications. 3993.
https://digitalscholar.lsuhsc.edu/som_facpubs/3993
10.3389/fped.2025.1571715
Included in
Congenital, Hereditary, and Neonatal Diseases and Abnormalities Commons, Hemic and Lymphatic Diseases Commons, Pathological Conditions, Signs and Symptoms Commons, Pediatrics Commons