A Preliminary Analysis of the Incidence of Transaminitis Observed in Oxandrolone Versus Testosterone Therapy in Major Burn Injury
Document Type
Article
Publication Date
6-26-2025
Publication Title
Journal of burn care & research : official publication of the American Burn Association
Abstract
After major burn injury, patients experience a hypermetabolic response leading to catabolic effects. Anabolic steroids have been investigated to combat these effects. Oxandrolone, the primary anabolic steroid used to combat burn hypermetabolism, was removed from the U.S. market in June 2023, and our institution implemented testosterone as an alternative. A known side effect of anabolic steroid use is transaminitis. This study aims to compare the incidence of transaminitis between oxandrolone and testosterone in patients with major burn injury. A single-center, retrospective cohort was conducted to evaluate adult patients with at least 20% body surface area burn injury who received either testosterone or oxandrolone. The primary outcome evaluated was incidence of transaminitis. Secondary outcomes included the need for dose reduction or discontinuation of the steroid, length of stay, and mortality. Preliminary data was analyzed for significance. Seventy patients received either oxandrolone (n = 52) or testosterone (n = 18). Demographics were similar. The incidence of transaminitis was not statistically significant between oxandrolone and testosterone, 38% vs 28% (p=.596). The rate of dose decrease between the two groups was not significant, 17% vs 0% (p=.071). There was a statistically significant difference in early discontinuation of the drug between the groups, 33% oxandrolone vs 0% testosterone (p=.014). The median length of stay was 28 and 36 days, respectively, with a mortality rate of 21% and 6% in each group. Preliminary data from this study demonstrate a trend to higher incidence of oxandrolone transaminitis in comparison to testosterone, without statistical significance.
PubMed ID
40568970
Recommended Citation
DeWitt, Alexandra; Hoppe, Athena; Ivanko, Anastasiya; Carter, Jeffrey E.; and Miles, Majel V., "A Preliminary Analysis of the Incidence of Transaminitis Observed in Oxandrolone Versus Testosterone Therapy in Major Burn Injury" (2025). School of Medicine Faculty Publications. 3945.
https://digitalscholar.lsuhsc.edu/som_facpubs/3945
10.1093/jbcr/iraf118