Integrative approaches to atrial fibrillation prevention and management: Leveraging gut health for improved cardiovascular outcomes in the aging population
Document Type
Article
Publication Date
12-1-2024
Publication Title
Current Problems in Cardiology
Abstract
Atrial fibrillation (AF) is a prevalent clinical arrhythmia associated with a high incidence and severe complications such as cerebral embolism and heart failure. While the etiology and pathogenesis of AF involve numerous factors, recent research emphasizes the significant role of intestinal microbiota imbalance in the emergence and progression of AF, particularly among older adults. This review investigates the mechanisms by which intestinal flora and their metabolites contribute to the onset of AF in the elderly, highlighting novel interactions between gut health and cardiac function. Current literature often overlooks these critical connections, indicating a substantial research gap in understanding how dysbiosis may exacerbate AF and hinder recovery. Furthermore, exploring the bidirectional relationship between the gut microbiome and systemic inflammation in the context of AF provides a unique perspective that has yet to be thoroughly investigated. Future research should focus on longitudinal studies assessing gut microbiota composition and function in AF patients and consider probiotics or prebiotics as potential adjunctive therapies for mitigating AF. This comprehensive approach may pave the way for innovative treatments integrating cardiology with gastroenterology, enhancing patient outcomes through a holistic understanding of health.
PubMed ID
39626858
Volume
50
Issue
3
Recommended Citation
Williams, Emma Grace; Alissa, Mohammed; Alsugoor, Mahdi H.; Albakri, Ghadah Shukri; Altamimi, Ali A.; Alabdullateef, Abdulmajeed Abdulaziz; Almansour, Nahlah Makki; Aldakheel, Fahad M.; Alessa, Salem; and Marber, Marber, "Integrative approaches to atrial fibrillation prevention and management: Leveraging gut health for improved cardiovascular outcomes in the aging population" (2024). School of Medicine Faculty Publications. 3718.
https://digitalscholar.lsuhsc.edu/som_facpubs/3718
10.1016/j.cpcardiol.2024.102952