CMR Findings in the Long-Term Outcomes After Multisystem Inflammatory Syndrome in Children (MUSIC) Study

Authors

• Sean M. Lang, Cincinnati Children's Hospital Medical Center
• Dongngan T. Truong, University of Utah School of Medicine
• Andrew J. Powell, Harvard Medical School
• Valiantsina Kazlova, Carelon, Inc.
• Jane W. Newburger, Harvard Medical School
• Jordan D. Awerbach, University of Arizona College of Medicine – Phoenix
• Edem Binka, University of Utah School of Medicine
• Tamara T. Bradford, LSU Health Sciences Center - New OrleansFollow
• Mark Cartoski, Alfred I. duPont Hospital for Children
• Andrew Cheng, Children's Hospital Los Angeles
• Michael P. DiLorenzo, Vagelos College of Physicians and Surgeons
• Audrey Dionne, Harvard Medical School
• Adam L. Dorfman, C.S. Mott Children's Hospital
• Matthew D. Elias, The Children's Hospital of Philadelphia
• Olukayode Garuba, Baylor College of Medicine
• Jennifer F. Gerardin, Medical College of Wisconsin
• Keren Hasbani, Dell Medical School
• Pei Ni Jone, Northwestern University Feinberg School of Medicine
• Christopher Z. Lam, The Hospital for Sick Children
• Nilanjana Misra, Cohen Children’s Medical Center
• Lerraughn M. Morgan, Valley Children's Healthcare
• Arni Nutting, Medical University of South Carolina
• Jyoti K. Patel, Indiana University School of Medicine
• Joshua D. Robinson, Northwestern University Feinberg School of Medicine
• Eleanor L. Schuchardt, Department of Pediatrics
• Kristen Sexson Tejtel, Baylor College of Medicine
• Gautam K. Singh, Children's Hospital of Michigan
• Timothy C. Slesnick, Emory University School of Medicine
• Felicia Trachtenburg, Carelon, Inc.
• et al

Document Type

Article

Publication Date

4-4-2025

Publication Title

Circulation: Cardiovascular Imaging

Abstract

BACKGROUND: Multisystem Inflammatory Syndrome in Children is characterized by high rates of acute cardiovascular involvement with rapid recovery of organ dysfunction. However, information regarding long-term sequelae is lacking. We sought to characterize the systolic function and myocardial tissue properties using cardiac magnetic resonance (CMR) imaging in a multicenter observational cohort of Multisystem Inflammatory Syndrome in Children patients. METHODS: In this observational cohort study, comprising 32 centers in North America, CMR studies were analyzed by a core laboratory to assess ventricular volumetric data, tissue characterization, and coronary involvement. RESULTS: A total of 263 CMRs from 255 Multisystem Inflammatory Syndrome in Children patients were analyzed. The mean patient age was 11.4±4.4 years. Most studies were performed at 3 months (33%) or 6 months (45%) after hospitalization. Left ventricular dysfunction was present in 17 (6.7%) of the first CMRs and was never worse than mild. Dysfunction was observed in 4/7 (57%) patients at admission, 5/87 (6.9%) patients at 3 months, and 6/129 (4.6%) patients imaged either at 6 months or 1 year post-hospitalization. Late gadolinium enhancement was present in 2 (0.8%) patients, 1 at 3 months and another at 6 months following hospitalization. Coronary artery dilation was present in 13 of the 174 (7.5%) patients. Nine patients met the Lake Louise criteria for myocarditis (3.5%) at the time of CMR. CONCLUSIONS: In this largest published multiinstitutional longitudinal CMR evaluation of confirmed Multisystem Inflammatory Syndrome in Children patients, the prevalence of ventricular dysfunction and myocardial tissue characterization abnormalities on medium-term follow-up was low. However, a small number of patients had mild residual abnormalities at 6 months and 1 year following hospitalization.

PubMed ID

40181776

Comments

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Recommended Citation

Lang, Sean M.; Truong, Dongngan T.; Powell, Andrew J.; Kazlova, Valiantsina; Newburger, Jane W.; Awerbach, Jordan D.; Binka, Edem; Bradford, Tamara T.; Cartoski, Mark; Cheng, Andrew; DiLorenzo, Michael P.; Dionne, Audrey; Dorfman, Adam L.; Elias, Matthew D.; Garuba, Olukayode; Gerardin, Jennifer F.; Hasbani, Keren; Jone, Pei Ni; Lam, Christopher Z.; Misra, Nilanjana; Morgan, Lerraughn M.; Nutting, Arni; Patel, Jyoti K.; Robinson, Joshua D.; Schuchardt, Eleanor L.; Tejtel, Kristen Sexson; Singh, Gautam K.; Slesnick, Timothy C.; Trachtenburg, Felicia; and al, et, "CMR Findings in the Long-Term Outcomes After Multisystem Inflammatory Syndrome in Children (MUSIC) Study" (2025). School of Medicine Faculty Publications. 3697.
https://digitalscholar.lsuhsc.edu/som_facpubs/3697
10.1161/CIRCIMAGING.124.017420