CMR Findings in the Long-Term Outcomes After Multisystem Inflammatory Syndrome in Children (MUSIC) Study

Sean M. Lang, Cincinnati Children's Hospital Medical Center
Dongngan T. Truong, University of Utah School of Medicine
Andrew J. Powell, Harvard Medical School
Valiantsina Kazlova, Carelon, Inc.
Jane W. Newburger, Harvard Medical School
Jordan D. Awerbach, University of Arizona College of Medicine – Phoenix
Edem Binka, University of Utah School of Medicine
Tamara T. Bradford, LSU Health Sciences Center - New OrleansFollow
Mark Cartoski, Alfred I. duPont Hospital for Children
Andrew Cheng, Children's Hospital Los Angeles
Michael P. DiLorenzo, Vagelos College of Physicians and Surgeons
Audrey Dionne, Harvard Medical School
Adam L. Dorfman, C.S. Mott Children's Hospital
Matthew D. Elias, The Children's Hospital of Philadelphia
Olukayode Garuba, Baylor College of Medicine
Jennifer F. Gerardin, Medical College of Wisconsin
Keren Hasbani, Dell Medical School
Pei Ni Jone, Northwestern University Feinberg School of Medicine
Christopher Z. Lam, The Hospital for Sick Children
Nilanjana Misra, Cohen Children’s Medical Center
Lerraughn M. Morgan, Valley Children's Healthcare
Arni Nutting, Medical University of South Carolina
Jyoti K. Patel, Indiana University School of Medicine
Joshua D. Robinson, Northwestern University Feinberg School of Medicine
Eleanor L. Schuchardt, Department of Pediatrics
Kristen Sexson Tejtel, Baylor College of Medicine
Gautam K. Singh, Children's Hospital of Michigan
Timothy C. Slesnick, Emory University School of Medicine
Felicia Trachtenburg, Carelon, Inc.
et al

Document Type

Article

Publication Date

4-4-2025

Publication Title

Circulation: Cardiovascular Imaging

Abstract

BACKGROUND: Multisystem Inflammatory Syndrome in Children is characterized by high rates of acute cardiovascular involvement with rapid recovery of organ dysfunction. However, information regarding long-term sequelae is lacking. We sought to characterize the systolic function and myocardial tissue properties using cardiac magnetic resonance (CMR) imaging in a multicenter observational cohort of Multisystem Inflammatory Syndrome in Children patients. METHODS: In this observational cohort study, comprising 32 centers in North America, CMR studies were analyzed by a core laboratory to assess ventricular volumetric data, tissue characterization, and coronary involvement. RESULTS: A total of 263 CMRs from 255 Multisystem Inflammatory Syndrome in Children patients were analyzed. The mean patient age was 11.4±4.4 years. Most studies were performed at 3 months (33%) or 6 months (45%) after hospitalization. Left ventricular dysfunction was present in 17 (6.7%) of the first CMRs and was never worse than mild. Dysfunction was observed in 4/7 (57%) patients at admission, 5/87 (6.9%) patients at 3 months, and 6/129 (4.6%) patients imaged either at 6 months or 1 year post-hospitalization. Late gadolinium enhancement was present in 2 (0.8%) patients, 1 at 3 months and another at 6 months following hospitalization. Coronary artery dilation was present in 13 of the 174 (7.5%) patients. Nine patients met the Lake Louise criteria for myocarditis (3.5%) at the time of CMR. CONCLUSIONS: In this largest published multiinstitutional longitudinal CMR evaluation of confirmed Multisystem Inflammatory Syndrome in Children patients, the prevalence of ventricular dysfunction and myocardial tissue characterization abnormalities on medium-term follow-up was low. However, a small number of patients had mild residual abnormalities at 6 months and 1 year following hospitalization.

PubMed ID

40181776

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