Alcohol Exposure Among Patients With Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study

Authors

Javier Jimenez, Baptist Cardiac and Vascular Institute
Hanyu Ni, Ohio State University - Columbus
Stuart D. Katz, NYU Grossman School of Medicine
Garrie J. Haas, Dorothy M. Davis Heart and Lung Research Institute
Jinwen Cao, Ohio State University - Columbus
Muni Rubens, Herbert Wertheim College of Medicine
Sandra Chaparro, Baptist Cardiac and Vascular Institute
Anshul Saxena, Baptist Health South Florida
Mark Hofmeyer, MedStar Research Institute, Washington DC
Evan Kransdorf, Cedars-Sinai Medical Center
Gregory A. Ewald, Washington University in St. Louis
Alanna A. Morris, Emory University School of Medicine
Anjali Owens, University of Pennsylvania Perelman School of Medicine
Brian Lowes, University of Nebraska Medical Center
Douglas Stoller, University of Nebraska Medical Center
W. H.Wilson Tang, Cleveland Clinic Foundation
Palak Shah, Inova Heart and Vascular Institute
Jane E. Wilcox, Northwestern University Feinberg School of Medicine
Frank Smart, LSU Health Sciences Center - New OrleansFollow
Jessica Wang, Ronald Reagan UCLA Medical Center
Stephen S. Gottlieb, University of Maryland School of Medicine
Daniel P. Judge, Medical University of South Carolina
Jonathan O. Mead, Ohio State University - Columbus
Natalie Hurst, Ohio State University - Columbus
Patricia K. Parker, Ohio State University - Columbus
Gordon S. Huggins, Tufts Medical Center
Elizabeth Jordan, Ohio State University - Columbus
Daniel D. Kinnamon, Ohio State University - Columbus
Ray E. Hershberger, Ohio State University - Columbus

Document Type

Article

Publication Date

3-28-2025

Publication Title

Circulation: Genomic and Precision Medicine

Abstract

BACKGROUND: Whether prolonged and excessive alcohol consumption contributes to dilated cardiomyopathy (DCM) remains uncertain. This study aimed to describe the prevalence of alcohol use in patients with DCM and their first-degree relatives (FDRs) and determine if cumulative alcohol exposure associates with DCM/partial DCM or modifies the association of DCM with DCM-relevant rare variants. METHODS: All probands had DCM; FDRs were classified as with or without DCM or partial DCM. Alcohol exposure was measured with the Alcohol Use Disorder Identification Test-Consumption questionnaire and years of drinking. Rare variants in 36 DCM genes were classified as pathogenic, likely pathogenic, or variants of uncertain significance (pathogenic, likely pathogenic, variant of uncertain significance). Generalized linear mixed models were used to assess the association of DCM/partial DCM with alcohol use among FDRs. RESULTS: DCM/partial DCM was found in 21.8% of 1373 FDRs of 1148 DCM probands. The prevalence of former or current alcohol use was 68% for probands and 70% for FDRs. About 30% of probands and 37% of FDRs had positive Alcohol Use Disorder Identification Test-Consumption scores, indicating moderate or heavy drinking. Among FDRs, DCM/partial DCM was associated with the presence of pathogenic/likely pathogenic variants in DCM genes (odds ratio, 3.51 [95% CI, 2.33-5.29]) but not with alcohol exposure. Cumulative alcohol exposure was not found to modify the association between DCM/partial DCM and these variants (P=0.55). CONCLUSIONS: Alcohol use was frequent among probands and FDRs. This study did not provide evidence supporting an association of cumulative alcohol exposure with DCM/partial DCM or a modifying effect of alcohol use on the association of DCM with DCM-relevant rare variants. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03037632.

First Page

153

Last Page

162

PubMed ID

40151927

Volume

18

Issue

2

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