Document Type
Article
Publication Date
11-26-2024
Publication Title
Molecular Therapy: Oncology
Abstract
Members of the Vesiculovirus genus including Jurona virus (JURV) have emerged as promising immunotherapeutic agents, characterized by their tumor selectivity, fast kinetics, low seroprevalence, and minimal toxicity in humans. Here, we demonstrate that the administration of JURV leads to tumor regression in both hepatocellular carcinoma (HCC) xenograft and syngeneic models. Furthermore, our findings indicate that combining JURV and anti-PD-1 therapy reduced tumor burden and improved survival rates over JURV or anti-PD-1 alone in an orthotopic HCC model. Proteogenomic analysis of JURV-treated, murine HCC tumors demonstrates that the therapeutic effects of the combination of JURV and anti-PD-1 are predominantly driven by coordinated activation of immune effectors, which modulate the tumor microenvironment into a state conducive to anti-tumor activity. Our results establish JURV as a potent candidate for immunovirotherapy in HCC, capable of modulating immune response and synergizing with standard of care for HCC to prolong survival in preclinical models. Further, this research deepens our understanding of JURV's anti-tumoral mechanisms and highlights its potential as a novel approach to HCC treatment strategies.
First Page
200913
PubMed ID
39758249
Volume
32
Issue
4
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Tesfay, Mulu Z.; Zhang, Yuguo; Ferdous, Khandoker U.; Taylor, Mika A.; Cios, Aleksandra; Shelton, Randal S.; Simoes, Camila C.; Watters, Chelsae R.; Barro, Oumar; Elliott, Natalie M.; Mustafa, Bahaa; Chamcheu, Jean Christopher; Graham, Alicia L.; Washam, Charity L.; Alkam, Duah; Gies, Allen; Byrum, Stephanie D.; Giorgakis, Emmanouil; Post, Steven R.; Kelly, Thomas; Ying, Jun; Moaven, Omeed; Chabu, Chiswili Y.; Fernandez-Zapico, Martin E.; Duda, Dan G.; Roberts, Lewis R.; Govindarajan, Rang; Borad, Mitesh J.; Cannon, Martin J.; and al, et, "Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade" (2024). School of Medicine Faculty Publications. 3387.
https://digitalscholar.lsuhsc.edu/som_facpubs/3387
10.1016/j.omton.2024.200913