Document Type
Article
Publication Date
11-4-2024
Publication Title
JAMA Network - Open
Abstract
IMPORTANCE: Traditional approaches to practice guidelines frequently result in dissociation between strength of recommendation and quality of evidence. OBJECTIVE: To create a clinical guideline for the diagnosis and management of urinary tract infections that addresses the gap between the evidence and recommendation strength. EVIDENCE REVIEW: This consensus statement and systematic review applied an approach previously established by the WikiGuidelines Group to construct collaborative clinical guidelines. In May 2023, new and existing members were solicited for questions on urinary tract infection prevention, diagnosis, and management. For each topic, literature searches were conducted up until early 2024 in any language. Evidence was reported according to the WikiGuidelines charter: clear recommendations were established only when reproducible, prospective, controlled studies provided hypothesis-confirming evidence. In the absence of such data, clinical reviews were developed discussing the available literature and associated risks and benefits of various approaches. FINDINGS: A total of 54 members representing 12 countries reviewed 914 articles and submitted information relevant to 5 sections: prophylaxis and prevention (7 questions), diagnosis and diagnostic stewardship (7 questions), empirical treatment (3 questions), definitive treatment and antimicrobial stewardship (10 questions), and special populations and genitourinary syndromes (10 questions). Of 37 unique questions, a clear recommendation could be provided for 6 questions. In 3 of the remaining questions, a clear recommendation could only be provided for certain aspects of the question. Clinical reviews were generated for the remaining questions and aspects of questions not meeting criteria for a clear recommendation. CONCLUSIONS AND RELEVANCE: In this consensus statement that applied the WikiGuidelines method for clinical guideline development, the majority of topics relating to prevention, diagnosis, and treatment of urinary tract infections lack high-quality prospective data and clear recommendations could not be made. Randomized clinical trials are underway to address some of these gaps; however further research is of utmost importance to inform true evidence-based, rather than eminence-based practice.
First Page
e2444495
PubMed ID
39495518
Volume
7
Issue
11
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Nelson, Zachary; Tarik Aslan, Abdullah; Beahm, Nathan P.; Blyth, Michelle; Cappiello, Matthew; Casaus, Danielle; Dominguez, Fernando; Egbert, Susan; Hanretty, Alexandra; Khadem, Tina; Olney, Katie; Abdul-Azim, Ahmed; Aggrey, Gloria; Anderson, Daniel T.; Barosa, Mariana; Bosco, Michael; Chahine, Elias B.; Chowdhury, Souradeep; Christensen, Alyssa; de Lima Corvino, Daniela; Fitzpatrick, Margaret; Fleece, Molly; Footer, Brent; Fox, Emily; Ghanem, Bassam; Hamilton, Fergus; Hayes, Justin; Jegorovic, Boris; Jent, Philipp; and al, et, "Guidelines for the Prevention, Diagnosis, and Management of Urinary Tract Infections in Pediatrics and Adults: A WikiGuidelines Group Consensus Statement" (2024). School of Medicine Faculty Publications. 3241.
https://digitalscholar.lsuhsc.edu/som_facpubs/3241
10.1001/jamanetworkopen.2024.44495
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Community Health and Preventive Medicine Commons, Diagnosis Commons, Therapeutics Commons, Urogenital System Commons