Document Type
Article
Publication Date
10-7-2024
Publication Title
Transfusion
Abstract
Background: Acute chest syndrome (ACS) is the leading cause of mortality, accounting for 25% of all deaths among individuals with sickle cell disease (SCD). There is a lack of evidence-based laboratory and clinical risk stratification guidelines for the diagnosis and management of ACS. Study Design and Methods: To better understand physician practices for the management of ACS in the United States, we created an ACS Working Group including hematology and transfusion medicine physicians from four different SCD treatment centers in the United States. The working group created a physician survey that included physician demographics and ACS diagnostic criteria that they had to rate. The survey also included three case scenarios to assess physician attitudes about the management of ACS. Management options included supportive and preventive strategies in addition to transfusion therapy options. Results: Out of 455 physicians who received the survey, 195 responded (response rate = 43%). The respondents were primarily hematology/oncology physicians. The responses showed wide variability among physicians in how diagnostic criteria for ACS are used and how physicians risk-stratify ACS patients in their practice. The responses also reflected variability in the use of transfusions for ACS. Discussion: Based on our results, we conclude that ACS is diagnosed and managed inconsistently among expert physicians, especially in their transfusion practices due to a lack of consensus on risk stratification criteria. Our data suggest an urgent need for well-designed prospective studies to provide evidence-based guidelines and minimize management variability among physicians who care for individuals with SCD and ACS.
PubMed ID
39373054
Chapter Title
18034 - Physician perspectives about the diagnosis and management of acute chest syndrome
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Recommended Citation
Bhasin, Neha; LeBlanc, Dana Marie; Yates, Sean; Eichbaum, Quentin; Pham, An; Sharma, Deva; Zhang, Li; Vichinsky, Elliott P.; and Sarode, Ravi, "Physician perspectives about the diagnosis and management of acute chest syndrome" (2024). School of Medicine Faculty Publications. 2996.
https://digitalscholar.lsuhsc.edu/som_facpubs/2996
10.1111/trf.18034
Included in
Hematology Commons, Hemic and Lymphatic Diseases Commons, Patient Safety Commons, Respiratory System Commons, Respiratory Tract Diseases Commons