Autoimmunity Roots of the Thrombotic Events After COVID-19 Vaccination
Document Type
Article
Publication Date
11-1-2021
Publication Title
Autoimmunity Reviews
Abstract
Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.
First Page
1
Last Page
6
PubMed ID
34508917
Volume
20
Issue
11
Publisher
Elsevier
Recommended Citation
Elrashdy, Fatma; Tambuwala, Murtaza M.; Hassan, Sk Sarif; Adadi, Parise; Seyran, Murat; Abd El-Aziz, Tarek Mohamed; Rezaei, Nima; Lal, Amos; Aljabali, Alaa A.A.; Kandimalla, Ramesh; Bazan, Nicolas G.; Azad, Gajendra Kumar; Sherchan, Samendra P.; Choudhury, Pabitra Pal; Serrano-Aroca, Ángel; Takayama, Kazuo; Chauhan, Gaurav; Pizzol, Damiano; Barh, Debmalya; and Panda, Pritam Kumar, "Autoimmunity Roots of the Thrombotic Events After COVID-19 Vaccination" (2021). School of Medicine Faculty Publications. 28.
https://digitalscholar.lsuhsc.edu/som_facpubs/28