Document Type
Article
Publication Date
7-19-2023
Publication Title
ACG Case Reports Journal
Abstract
Hereditary diffuse gastric cancer is a familial form of poorly differentiated signet ring cell carcinoma (SRCC) caused by a mutation in the CDH1/E-cadherin gene-mediating cell adhesion. CDH1 mutations are inherited in an autosomal dominant fashion and exhibit a high level of penetrance. SRCC diagnosis is exceedingly rare in the pediatric population. We report a case of SRCC in 2 sisters (10 and 15 years) and their father (41 years).
PubMed ID
37476473
Volume
10
Issue
7
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Falgout, Lacey and Gensler, Lawrence L., "Two Pediatric Cases Within a Familial Cluster and Hereditary Diffuse Gastric Carcinoma: A Tale of 2 Sisters" (2023). School of Medicine Faculty Publications. 2732.
https://digitalscholar.lsuhsc.edu/som_facpubs/2732
10.14309/crj.0000000000001100
