Document Type
Article
Publication Date
6-19-2024
Publication Title
Journal of Diabetes and its Complications
Abstract
The proposed glucosylamine oxidation pathway (GOP) is a two-step, intraerythrocyte, thermodynamically favorable nonenzymatic reaction that first binds glucose to the N-terminal valine of beta globin (βVal1) to form a closed-chain glucosylamine that can spontaneously reduce oxidized vitamin C to its antioxidant form. This review summarizes analytical, biochemical and clinical research supporting the existence of the GOP and the surprising hypothesis that βVal1 glucosylamine is a reducing agent that works cooperatively with reduced glutathione to dynamically regulate vitamin C recycling during naturally occurring periods of transiently or chronically elevated blood glucose and oxidant production. Rationale for the existence of the GOP is presented from the perspective of the hemoglobin glycation index, a clinically practical biomarker of risk for chronic vascular disease that we propose is mechanistically explained by person-to-person variation in GOP activity.
PubMed ID
38909585
Volume
38
Issue
8
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Hempe, James M.; Hsia, Daniel S.; Hagar, Arthur; and Byers, Larry, "The glucosylamine oxidation pathway of vitamin C recycling" (2024). School of Medicine Faculty Publications. 2715.
https://digitalscholar.lsuhsc.edu/som_facpubs/2715
10.1016/j.jdiacomp.2024.108797
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