Sleep apnea and ischemic stroke- a perspective for translational preclinical modelling

Authors

Ifechukwude J. Biose, LSU Health Sciences Center - New OrleansFollow
A B. Bakare, Tulane University, New Orleans, LA
H Wang, Tulane University School of Medicine, New Orleans, LA
T E. Gressett, Tulane University, New Orleans, LA
G J. Bix, Tulane University School of Medicine, New Orleans, LA

Document Type

Article

Publication Date

4-1-2024

Publication Title

Sleep Medicine Reviews

Abstract

Obstructive sleep apnea (OSA) is associated with ischemic stroke. There is, however, a lack of knowledge on the exact cause-effect relationship, and preclinical models of OSA for experimental ischemic stroke investigations are not well characterized. In this review, we discuss sleep apnea and its relationship with stroke risk factors. We consider how OSA may lead to ischemic stroke and how OSA-induced metabolic syndrome and hypothalamic-pituitary axis (HPA) dysfunction could serve as therapeutic targets to prevent ischemic stroke. Further, we examine the translational potential of established preclinical models of OSA. We conclude that metabolic syndrome and HPA dysfunction, which are often overlooked in the context of experimental stroke and OSA studies, are crucial for experimental consideration to improve the body of knowledge as well as the translational potential of investigative efforts.

First Page

101929

PubMed ID

38581800

Volume

75

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Recommended Citation

Biose, Ifechukwude J.; Bakare, A B.; Wang, H; Gressett, T E.; and Bix, G J., "Sleep apnea and ischemic stroke- a perspective for translational preclinical modelling" (2024). School of Medicine Faculty Publications. 2604.
https://digitalscholar.lsuhsc.edu/som_facpubs/2604
10.1016/j.smrv.2024.101929