Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation

Authors

Jungang Chen, University of Arkansas for Medical Sciences
Luis Del Valle, LSU Health Sciences Center - New OrleansFollow
Hui-Yi Lin, LSU Health Sciences Center - New OrleansFollow
Karlie Plaisance-Bonstaff, LSU Health Sciences Center - New OrleansFollow
J Craig Forrest, University of Arkansas for Medical Sciences
Steven R. Post, University of Arkansas for Medical Sciences
Zhiqiang Qin, University of Arkansas for Medical Sciences

Document Type

Article

Publication Date

7-30-2019

Publication Title

Virology

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) causes several cancers such as Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). PD-1/PD-Ls immune checkpoint molecules play important roles in cancer cell immune escape. The expression of PD-1/PD-Ls and their regulation by oncogenic viruses, in particular KSHV, remain largely undefined. Here we demonstrate strong PD-1/PD-L1/PD-L2 expression in KS tissues from a cohort of HIV + patients. We found that induction of KSHV lytic reactivation significantly upregulates PD-L1 expression on infected tumor cells, potentially through several major cellular signaling pathways and IL-1β, which may represent a novel mechanism for virus-associated tumor cell immune escape.

First Page

16

Last Page

19

PubMed ID

31394407

Volume

536

Recommended Citation

Chen, Jungang; Del Valle, Luis; Lin, Hui-Yi; Plaisance-Bonstaff, Karlie; Forrest, J Craig; Post, Steven R.; and Qin, Zhiqiang, "Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation" (2019). School of Medicine Faculty Publications. 2274.
https://digitalscholar.lsuhsc.edu/som_facpubs/2274
10.1016/j.virol.2019.07.024