Emmprin and KSHV: new partners in viral cancer pathogenesis
Document Type
Article
Publication Date
6-3-2013
Publication Title
Cancer Letters
Abstract
Emmprin (CD147; basigin) is a multifunctional glycoprotein expressed at higher levels by cancer cells and stromal cells in the tumor microenvironment. Through direct effects within tumor cells and promotion of tumor-stroma interactions, emmprin participates in induction of tumor cell invasiveness, angiogenesis, metastasis and chemoresistance. Although its contribution to cancer progression has been widely studied, the role of emmprin in viral oncogenesis still remains largely unclear, and only a small body of available literature implicates emmprin-associated mechanisms in viral pathogenesis and tumorigenesis. We summarize these data in this review, focusing on the role of emmprin in pathogenesis associated with the Kaposi sarcoma-associated herpesvirus (KSHV), a common etiology for cancers arising in the setting of immune suppression. We also discuss future directions for mechanistic studies exploring roles for emmprin in viral cancer pathogenesis.
First Page
161
Last Page
6
PubMed ID
23743354
Volume
337
Issue
2
Recommended Citation
Dai, Lu; Bai, Lihua; Lu, Ying; Xu, Zengguang; Reiss, Krys; Del Valle, Luis; Kaleeba, Johnan; Toole, Bryan P.; Parsons, Chris; and Qin, Zhiqiang, "Emmprin and KSHV: new partners in viral cancer pathogenesis" (2013). School of Medicine Faculty Publications. 2271.
https://digitalscholar.lsuhsc.edu/som_facpubs/2271