In vitro models of HIV-1 infection of the Central Nervous System

Authors

Celeste Faia, LSU Health Sciences Center - New Orleans
Karlie Plaisance-Bonstaff, LSU Health Sciences Center - New Orleans
Francesca Peruzzi, LSU Health Sciences Center - New OrleansFollow

Document Type

Article

Publication Date

12-20-2019

Publication Title

Drug Discovery Today. Disease Models

Abstract

Neurocognitive disorders associated with HIV-1 infection affect more than half of persons living with HIV (PLWH) under retroviral therapy. Understanding the molecular mechanisms and the complex cellular network communication underlying neurological dysfunction is critical for the development of an effective therapy. As with other neurological disorders, challenges to studying HIV infection of the brain include limited access to clinical samples and proper reproducibility of the complexity of brain networks in cellular and animal models. This review focuses on cellular models used to investigate various aspects of neurological dysfunction associated with HIV infection.

First Page

5

Last Page

11

PubMed ID

33692833

Volume

32

Issue

Pt A

Recommended Citation

Faia, Celeste; Plaisance-Bonstaff, Karlie; and Peruzzi, Francesca, "In vitro models of HIV-1 infection of the Central Nervous System" (2019). School of Medicine Faculty Publications. 1997.
https://digitalscholar.lsuhsc.edu/som_facpubs/1997
10.1016/j.ddmod.2019.10.007