Document Type
Article
Publication Date
7-1-2020
Publication Title
JACC: Basic to Translational Science
Abstract
With the complexities that surround myocardial ischemia/reperfusion (MI/R) injury, therapies adjunctive to reperfusion that elicit beneficial pleiotropic effects and do not overlap with standard of care are necessary. This study found that the mitochondrial-derived peptide S14G-humanin (HNG) (2 mg/kg), an analogue of humanin, reduced infarct size in a large animal model of MI/R. However, when ischemic time was increased, the infarct-sparing effects were abolished with the same dose of HNG. Thus, although the 60-min MI/R study showed that HNG cardioprotection translates beyond small animal models, further studies are needed to optimize HNG therapy for longer, more patient-relevant periods of cardiac ischemia.
First Page
699
Last Page
714
PubMed ID
32760857
Volume
5
Issue
7
Recommended Citation
Sharp, Thomas E.; Gong, Zhenwei; Scarborough, Amy; Goetzman, Eric S.; Ali, Murtuza J.; Spaletra, Pablo; Lefer, David J.; Muzumdar, Radhika H.; and Goodchild, Traci T., "Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury" (2020). School of Medicine Faculty Publications. 1984.
https://digitalscholar.lsuhsc.edu/som_facpubs/1984
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