Physical Activity In Stage Iii Colon Cancer: Calgb/swog 80702 (alliance)
Document Type
Article
Publication Date
9-9-2022
Publication Title
Journal of Clinical Oncology
Abstract
PURPOSE To determine the specific types, durations, and intensities of recreational physical activity associated with the greatest improvements in disease-free survival (DFS) of patients with colon cancer.
METHODS We conducted a prospective cohort study nested within a randomized multicenter trial of stage III colon cancer that compared 3 versus 6 months of fluorouracil, leucovorin, and oxaliplatin with or without celecoxib. We measured recreational physical activity in the first 3 months of chemotherapy and again 6 months after completion of chemotherapy. The primary end point was DFS.
RESULTS During a median follow-up of 5.9 years, 457 of 1,696 patients experienced disease recurrence or death. For total recreational physical activity volume, the 3-year DFS was 76.5% with < 3.0 metabolic equivalent task hours per week (MET-h/wk) and 87.1% with ≥ 18.0 MET-h/wk (risk difference [RD], 10.6%; 95% CI, 4.7 to 19.4; P <.001). For light-intensity to moderate-intensity activities, the 3-year DFS was 65.7% with 0.0 h/wk and 87.1% with ≥ 1.5 h/wk (RD, 21.4%; 95% CI, 9.2 to 37.1; P <.001). For vigorous-intensity activity, the 3-year DFS was 76.0% with 0.0 h/wk and 86.0% with ≥ 1.0 h/wk (RD, 10.0%; 95% CI, 4.5 to 18.9; P <.001). For brisk walking, the 3-year DFS was 81.7% with < 1.0 h/wk and 88.4% with ≥ 3.0 h/wk (RD, 6.7%; 95% CI, 3.0 to 13.8; P <.001). For muscle strengthening activity, the 3-year DFS was 81.8% with 0.0 h/wk and 88.8% for ≥ 0.5 h/wk (RD, 7.0%; 95% CI, 3.1 to 14.2; P =.003).CONCLUSIONAmong patients with stage III colon cancer enrolled in a trial of postoperative treatment, larger volumes of recreational physical activity, longer durations of light- to moderate-intensity aerobic physical activity, or any vigorous-intensity aerobic physical activity were associated with the greatest improvements in DFS.
First Page
243
Last Page
254
PubMed ID
35944235
Volume
41
Issue
2
Recommended Citation
Brown, Justin C.; Ma, Chao; Shi, Qian; Fuchs, Charles S.; Meyer, Jeffrey; Niedzwiecki, Donna; Zemla, Tyler; Couture, Felix; Kuebler, Philip; Kumar, Pankaj; Lewis, Dequincy; Tan, Benjamin; Krishnamurthi, Smitha; O'Reilly, Eileen M.; Shields, Anthony F.; and Meyerhardt, Jeffrey A., "Physical Activity In Stage Iii Colon Cancer: Calgb/swog 80702 (alliance)" (2022). School of Medicine Faculty Publications. 1937.
https://digitalscholar.lsuhsc.edu/som_facpubs/1937