Document Type
Article
Publication Date
11-1-2021
Publication Title
PLoS ONE
Abstract
In the current study, we analyzed the effects of the systemic inflammatory response (SIR) and amyloid β (Aβ) peptide on the expression of genes encoding cyclins and cyclin-dependent kinase (Cdk) in: (i) PC12 cells overexpressing human beta amyloid precursor protein (βAPP), wild-type (APPwt-PC12), or carrying the Swedish mutantion (APPsw-PC12); (ii) the murine hippocampus during SIR; and (iii) Alzheimer’s disease (AD) brain. In APPwtPC12 expression of cyclin D2 (cD2) was exclusively reduced, and in APPsw-PC12 cyclins cD2 and also cA1 were down-regulated, but cA2, cB1, cB2, and cE1 were up-regulated. In the SIR cD2, cB2, cE1 were found to be significantly down-regulated and cD3, Cdk5, and Cdk7 were significantly up-regulated. Cyclin cD2 was also found to be down-regulated in AD neocortex and hippocampus. Our novel data indicate that Aβ peptide and inflammation both significantly decreased the expression of cD2, suggesting that Aβ peptides may also contribute to downregulation of cD2 in AD brain.
First Page
1
Last Page
16
PubMed ID
34793515
Volume
16
Issue
11 November
Publisher
Public Library of Science
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Strosznajder, Joanna B.; Czapski, Grzegorz A.; Cieślik, Magdalena; Białopiotrowicz, Emilia; and Lukiw, Walter J., "Down-Regulation of Cyclin D2 in Amyloid β Toxicity, Inflammation, and Alzheimer’s Disease" (2021). School of Medicine Faculty Publications. 156.
https://digitalscholar.lsuhsc.edu/som_facpubs/156
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